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Hereditary Amyloid Neuropathy
Elderly female with amyloid neuropathy of the sural nerve. Cross-sections of the left sural nerve prepared from formalin-fixed paraffin-embedded (FFPE)…
Peripheral Nerve Myelinating Cells
Figure 1 shows a myelin sheath (arrow) with orderly myelin wrapping. No abnormality of myelin periodicity is seen (i.e. no…
Immuno-Profile of WHO Grade I Meningiomas
The patient is a 50-year-old male who presents with a chief complaint of generalized headaches. Neuroimaging reveals a 3.5 cm…
Ganglioglioma, BRAF V600E-Mutated
Continuing on from the clinical vignette last week, a young adult female presents with generalized headaches of several months duration.…
Ganglioglioma, WHO grade I
Ganglioglioma (GG) A young adult female presents with generalized headaches of several months duration, which recently progressed in intensity with…
Lobulated Muscle Fibers with Wedge-shaped Accumulations of Mitochondria
Figure 1 and 2: Lobulated Muscle Fibers with Wedge-shaped Accumulations of Mitochondria. Frozen sections of skeletal muscle stained with NADH-TR…
4th of July Muscle Fibers
Neuro Notes is celebrating Old Glory this Independence Day with Red, White, and Blue Muscle Fibers! Happy 4th of July.…
Lobulated Muscle Fibers
Figure 1: Hereditary myopathy with lobulated muscle fibers in an elderly male presenting with myalgias. The photomicrograph shows snap frozen…
Acquired Etiologies of Myopathy with Lobulated Muscle Fibers
An elderly male patient presents with a chief complaint of dull achy pain. The patient relates that the pain is…
C9orf72 Gene
The patient is a middle-aged Caucasian male who presents with chief complaint of progressive muscle weakness and muscle cramps of…
U1-RNP-Related Myositis/Myopathy
The patient is an elderly female who presents with chief complaint of progressive symmetric proximal muscle weakness over the…
Neuromuscular Junctions
Neuromuscular junctions in normal skeletal muscle. Esterase preparation (A) darkly highlights neuromuscular junctions (NMJs) along a small intramuscular nerve twig.…
Alkaline Phosphatase in Muscle Biopsies
An elderly female in her mid-70s presents with insidiously progressive severe proximal muscle weakness over the last two to three…
Gonadotroph Adenoma
The patient is an obese middle-aged male who presents with complaints of headaches, vision changes, and loss of libido. Neuroimaging…
Cerebral Amyloid Angiopathy
The patient is a male in his 7th decade who presents with left occipital hemorrhagic stroke. The patient has a…