Clinical History
- 68-year-old woman with dysphagia, dysarthria, facial muscle weakness and rash
- Past medical history – breast cancer
- Medications –hydroxychloroquine and IVIG (at time of biopsy)
What is the process?
A. Dermatomyositis with treatment effect
B. Amyotrophic dermatomyositis
C. Anti-synthetase syndrome
D. MxA-related myopathy
Correct answer: A.Dermatomyositis with treatment effect
Dermatomyositis (DM) with treatment effect
- MHC class I and C5b-9 positivity support inflammatory myopathy
- CD3 + infiltrate suppressed by immunomodulatory therapy
- Perifascicular alkaline phosphatase and MxA (surrogate for interferon-β) positivity in myofibers in DM even w/o perifascicular atrophy
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