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Diagnose This (April 8, 2019)

L. Nich Cossey, MD
By L. Nich Cossey, MD

Apr 08, 2019

thrombotic microangiopathy, fibrin, arkana laboratories, renal pathology, nephropathology
Camera information: Calibration= 1.000 Pixels per pixel; Capture format= 1392 x 1040, Full Frame HQ; Gamma= 0.78; Gain= 1.0 x; Exposure= 6.85 ms; Auto exposure= On; Image type= Colour; Shading= (None); Sharpening= Off; Black clip= 10; White clip= 198; Microscope information:

What is your diagnosis?

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This image is of a silver stain showing an artery with a small arteriole budding off the right side. The artery shows mucoid intimal edema (the pale blue/purple) as well as near total lumen occlusion and focal fibrin deposition in the expanded intima. The arteriole shows lumen occlusion by intraluminal hyaline accumulation and focal fibrin deposition. These vascular findings are commonly seen in the setting of thrombotic microangiopathy, which is the diagnosis here. This patient presented with accelerated hypertension and subsequent renal failure. As the majority of the arteries show near total lumen occlusion, prognosis is guarded.

 

 

 

 

 

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Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.