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Thrombotic microangiopathy
Diagnose This!

Diagnose This (August 22, 2022)

This is a 3 month post-transplant kidney biopsy from a patient with ESRD due to polycystic kidney disease. She recently…

thrombotic microangiopathy
Diagnose This!

Diagnose This (January 10, 2022)

This is the H&E from the frozen tissue submitted for IF examined under fluorescent light. In a patient with anemia,…

anti-brush border antibody disease, ABBA, renal pathology, Twitter Poll, arkana labs
Twitter Poll

Twitter Poll (December 23, 2020)

Answer: D The histologic features of a thrombotic microangiopathy (TMA) are non-specific as to etiology and include both acute and…

Thrombotic Microangiopathy
Art of Medicine

Art of Medicine: Thrombotic Microangiopathy

The above painting shows a glomerulus containing capillary loop fibrin thrombi, an arteriole with onion-skinning, and acute tubular injury, findings…

KDIGO Connections

KDIGO Connections: SLE and TMA

Remember to think about TMA lesions in your patients with lupus!  

Disease Week, onco-nephrology, cancer, nephropathology
Disease Week

Disease Week: Onco-Nephrology

Monday Onco-nephrology is a rapidly developing area of nephrology designed to help address and prevent kidney problems and the many…

mesangiolysis, renal pathology, kidney biopsy stain, arkana laboratories
Diagnose This!

Diagnose This (August 5, 2019)

What is this finding in this native kidney? …

By L. Nich Cossey, MD
KDIGO Connections

KDIGO Connections: Atypical Hemolytic-Uremic Syndrome

How do you treat patients with atypical hemolytic-uremic syndrome? Learn more about treatment and atypical hemolytic-uremic syndrome through KDIGO Connections!…

Acute kidney injury, anti-centromere antibodies, ischemia, schistoctes, scleroderma renal crisis, thrombotic microangiopathy, scleroderma
Teaching Points


The patient is a 32-year-old African American female who presents with hypertensive urgency, positive ANA, positive anti-RNA polymerase III antibody,…

thrombotic microangiopathy, fibrin, arkana laboratories, renal pathology, nephropathology
By L. Nich Cossey, MD

Circumferential Mesangial Interposition

Mesangial cell interposition between GBMs is an unusual and not fully understood process. In this episode, Dr. Silva discusses where…

Fred Silva, MD renal pathologist at arkana laboratories
By Dr. Fred Silva
Scleroderma in a renal biopsy at Arkana Laboratories
Diagnose This!

Diagnose This (August 27, 2018)

What is this finding and what is the likely etiology? …

By L. Nich Cossey, MD

TMA, TMA Lesions with Multiple Etiologies
Twitter Poll

Twitter Poll (August 15, 2018)

ANSWER: D TMA is a lesion with multiple etiologies including HUS, TTP, STEC- HUS, complement dysregulation (atypical HUS), malignant HTN,…

By Vanessa Moreno, MD
Thrombotic Microangiopathy
Teaching Points

Endocapillary Hypercellularity in Thrombotic Microangiopathy

This renal biopsy performed on a 14-year-old boy shows changes diagnostic of a thrombotic microangiopathy (TMA). These changes include frequent…

Anti-VEGF Effect
Teaching Points

Anti-VEGF Effect

This biopsy was taken from an older adult man with acute kidney injury and non-nephrotic range proteinuria. His medical history…