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July 31, 2018

Endocapillary Hypercellularity in Thrombotic Microangiopathy

Thrombotic Microangiopathy

This renal biopsy performed on a 14-year-old boy shows changes diagnostic of a thrombotic microangiopathy (TMA). These changes include frequent fibrin thrombi within the arteriolar lumens and glomerular hilum, endothelial swelling, mesangiolysis and focal glomerular ischemic changes (Fig 1-3). Of note, the glomeruli frequently show marked global endocapillary hypercellularity, mostly composed of swollen endothelial cells and occasional circulating inflammatory cells (Fig 4). Immunofluorescence and electron microscopy show absence of immune complex deposition (not shown). This case illustrates that a subset of cases of TMA may show endocapillary hypercellularity and is important to avoid misdiagnosing such cases as a proliferative glomerulonephritis.   

Thrombotic Microangiopathy, endothelial swelling, mesangiolysis Thrombotic Microangiopathy, focal glomerular ischemic changes swollen endothelial cells and occasional circulating inflammatory cells