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Painful Ankle Mass

By Joshua Sonnen, MD

Nov 17, 2023

Degenerative axon/axonal-spheroid

Clinical History

  • 49-year-old woman
  • Right-sided sural nerve mass
  • Distal pain and numbness of the ankle

What is the structure at the blue arrowhead?

A. Degenerative axon/axonal-spheroid

B. Spheroid body

C. Lafora neurite

D. Lafora body/corpora amylacea


Correct answer: A. Degenerative axon/axonal-spheroid


Traumatic neuroma: axonal spheroid

Traumatic neuroma

  • Occur at site of prior transected nerve with disorganized repair
  • H&E: randomly oriented nerve “twigs” in haphazard fibrous background

Axonal spheroids

  • Subacute finding of transected axon; degenerates proximally
  • Toluidine blue stain: dilated axon with disorganized axoplasm within Schwan cell sheath


Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.