Clinical History
- 49-year-old woman
- Right-sided sural nerve mass
- Distal pain and numbness of the ankle
What is the structure at the blue arrowhead?
A. Degenerative axon/axonal-spheroid
B. Spheroid body
C. Lafora neurite
D. Lafora body/corpora amylacea
Correct answer: A. Degenerative axon/axonal-spheroid
Traumatic neuroma: axonal spheroid
Traumatic neuroma
- Occur at site of prior transected nerve with disorganized repair
- H&E: randomly oriented nerve “twigs” in haphazard fibrous background
Axonal spheroids
- Subacute finding of transected axon; degenerates proximally
- Toluidine blue stain: dilated axon with disorganized axoplasm within Schwan cell sheath
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