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Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice
In the U.S. about half of the HIV-infected individuals are aged 50 and older. In men living with HIV, secondary…
HIV-1 Tat Upregulates The Receptor For Advanced Glycation End Products And Superoxide Dismutase-2 In The Heart Of Transgenic Mice
Cardiovascular disorder (CVD) is a common comorbidity in people living with HIV (PLWH). Although the underlying mechanisms are unknown, virotoxic…
Traditional Indigenous Medicines Are An Etiologic Consideration For NELL1-positive Membranous Nephropathy
Traditional indigenous medicines (TIM) are founded on ancient historical practice. These medications are obtained over the counter, vary in composition,…
Independent Actions By Hiv-1 Tat And Morphine To Increase Recruitment Of Monocyte-Derived Macrophages Into The Brain In A Region-Specific Manner
Despite advances in the treatment of human immunodeficiency virus (HIV), approximately one-half of people infected with HIV (PWH) experience neurocognitive…
Clinicopathologic And Proteomic Characteristics Of Intratubular Cytoplasmic AL Amyloidosis
Urine Uromodulin As A Biomarker Of Kidney Tubulointerstitial Fibrosis
Uromodulin, produced exclusively in the kidney’s thick ascending limb, is a biomarker of kidney tubular health. However, the relationship between…
C3 Glomerulopathy Associated With Both Hypertensive Retinopathy And Purtscher-Like Retinopathy
This article reports the case of a 21-year-old woman with both hypertensive retinopathy and Purtscher-like retinopathy in association with C3…
The Alternative Pathway Is Necessary and Sufficient for Complement Activation by Anti-THSD7A Autoantibodies, Which Are Predominantly IgG4 in Membranous Nephropathy
Membranous nephropathy (MN) is an immune kidney disease characterized by glomerular subepithelial immune complexes (ICs) containing antigen, IgG, and products…
18F-MK-6240 tau-PET In Genetic Frontotemporal Dementia
Tau is one of several proteins associated with frontotemporal dementia. While knowing which protein is causing a patient’s disease is…
What Can Mercury Teach Us About Membranous Nephropathy and Minimal Change Disease?
From clinical associations of environmental exposure beginning with the story of cationic bovine serum in pediatric membranous nephropathy (MN) more…
Dual Diagnosis Of Histiocytoid Sweet Syndrome And Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Histiocytoid Sweet syndrome (H-SS) is a rare variant of acute febrile neutrophilic dermatosis. It isfrequently associated with hematologic malignancies but…
Cubilin And Amnionless Protein Are Novel Target Antigens In Anti-Brush Border Antibody Disease
The kidney proximal tubule reabsorbs large amounts of low-molecular-weight proteins, albumin, electrolytes, and solutes from the glomerular filtrate to the…
Collapsing Glomerulopathy In A Patient With Mixed Connective Tissue Disease
Collapsing glomerulopathy (CG) is a form of podocytopathy that is challenging to manage. CG can be idiopathic or associated with…
6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa And Mu Opioid Receptor Agonists As Analgesics Devoid Of Anxiogenic Effects
Current common analgesics are mediated through the mu or kappa opioid receptor agonism. Unfortunately, selective mu or kappa receptor agonists…
High-Speed Light-Sheet Microscopy For The In-Situ Acquisition Of Volumetric Histological Images Of Living Tissue
Histological examinations typically require the excision of tissue, followed by its fixation, slicing, staining, mounting and imaging, with timeframes ranging…