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Extrafusal and Intrafusal Fibers

Clinical History This 1-year-old patient underwent muscle biopsy to evaluate for hypotonia. What are the muscle fibers within the small…

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Diagnose This 4/15/2024

Based on the image provided, what would be your leading diagnosis with C3-dominant immune-complex deposition? The light microscopic image depicts…

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Signet Ring Carcinoma

Clinical History This 50-year-old patient presented with muscle weakness and stiffness. They had recently been identified to have diffuse thickening…

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Oxidative Stain Pallor

Clinical History This 60-year-old patient presented with progressive symmetrical subacute onset proximal muscle weakness involving their lower and upper extremities.…

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Diagnose This 4/1/2024

What is this finding and what is the significance in the transplant setting?   The light microscopic image depicts an…

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Diagnose This 3/18/2024

What is at the top of your differential in a patient with a positive SPEP (IgG kappa) and the immunofluorescence…

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Diagnose This 3/11/2024

What is your diagnosis in a patient with nephrotic syndrome? The electron photomicrograph demonstrates frequent subepithelial deposits along the glomerular…

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Diagnose This 3/4/2024

The ultrastructural abnormalities present in the image are suspicious for what underlying disease?   The electron photomicrograph demonstrates two abnormal…

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Denervated Schwann cell

Clinical History This 50-year-old previously healthy patient presented with a several year history of progressive numbness, tingling and distal lower…

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Diagnose This 2/26/2024

What is your diagnosis based on the EM image provided? The electron microscopy image provided is that of portions of…

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Regenerated Clusters

Clinical History This 60-year-old diabetic patient presented with complaints of bilateral chronic numbness and tingling involving their legs in a…

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Diagnose This 2/19/2024

What is your leading diagnosis when seeing this particular IgG staining pattern?     Answer: Fibrillary Glomerulopathy The immunofluorescence shows…

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Aaron Storey, PhD

Dr. Aaron Storey joined Arkana Labs in 2023 to direct the Mass Spectrometry Laboratory. Dr. Storey received his Bachelor of…

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Diagnose This 2/12/2024

What is your diagnosis?   The light microscopic image depicts a renal transplant biopsy with multiple histiocytes containing intracytoplasmic, targetoid…

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Unusual Inflammatory Neuropathy

Clinical History: This 60-year-old patient presented with a history of chronic progressive paresthesias involving all four extremities. Electrodiagnostic studies showed…

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