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Amyopathic Dermatomyositis in Children

Clinical History A 12-year-old girl presents with a chief complaint of progressive fatigue, weakness, and dyspnea on exertion, which has…

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Mitoses in Neoplastic Cells

Are the mitotic figures in the images from this epithelioid skull base neoplasm normal or abnormal?   Answer: These are…

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Adult Onset Pompe Disease/Acid Maltase Deficiency

Clinical History This patient presented with a several year history of muscle weakness. Muscle biopsy and genetic testing were performed.…

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Myopathy with Polyglucosan Bodies

Clinical History This 65-year-old patient with a history of severe osteoarthritis presented with muscle aches. Muscle biopsy was performed during…

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Macrophagic Myofasciitis

Clinical History This 60-year old patient presented with a several month history of progressive upper and lower extremity muscle weakness…

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AIDP / Guillain-Barré syndrome

Clinical History This 50-year old patient with a past medical history of gastric sleeve operation presented with a two week…

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Leg Muscle Pain

Clinical History 35-year-old previously healthy woman presented with dark urine, severe pain & swelling in bilateral lower extremity 1 day…

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Nemaline Myopathy

Clinical History 45-year-old woman with mild, symmetric, slowly-progressive upper and lower extremity weakness beginning in childhood. Her past medical history…

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Ring Fiber

Clinical History What is the finding in these electron micrographs and what is its clinical association? A. Ouroboros fiber …

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Glioblastoma with Mesenchymal Metaplasia

Clinical History This 80-year old patient presented with new onset seizures. Brain MRI demonstrated a 4.6 x 3.4 x 3.0…

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Fourth Ventricular Mass

Clinical History This 27-year-old patient presented with left leg numbness, low back pain and balance issues. MRI showed a 4.9…

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Dural Mass

Clinical History This 50-year-old patient was found to have in incidental dural based mass. What is your diagnosis? Correct Answer…

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Segmental Demyelination-Remyelination

What pathologic process is demonstrated by the low and higher magnification images of a teased nerve preparation? The image shows…

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Longstanding Weakness

Clinical History The patient is a 72-year-old man with a 30 year history progressive, symmetric leg weakness and tingling. Past…

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Muscle Pain

Clinical History The patient is a 54-year-old man with lower extremity pain and edema, weakness and fever following a respiratory…

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