ANSWER: C, Banff Class 3
The answer is C, Polyomavirus Nephropathy, Banff Class 3. The Banff Working Group Classification was created by Nickeleit et al. to provide a classification scheme to aid communication, better standardize reporting of polyomavirus nephropathy, and provide a way for better comparative analysis of cases going forward. The classification is broken into three classes, Banff Class 1-3. This case highlights an example of a Polyomavirus Nephropathy, Banff Class 3 with a pvl score of 3 and ci (fibrosis) score of 2. Based on this score, the findings of the Banff working group showed that approximately 50% of these patients would develop graft failure at 24 months.
Reference:
Nickeleit V et al. The Banff Working Group Classification of Definitive Polyomavirus Nephropathy: Morphologic Definitions and Clinical Correlations. J Am Soc Nephrol (2018) 29: 680-695.
Tags: polyomavirus, Banff, pvl score, ci score, transplant, PVN
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