arrow-right-realarrow-right-whitearrow-rightback-to-topdoctordownloadfacebookinstagramlogo-markerlogo-wordmarkpodcastsearchsearch_whitetwitter
Close Modal
0

Blog


June 17, 2019

Twitter Poll (June 13, 2019)

ANSWER: D

The use of anticoagulant therapy (warfarin, dabigatran, rivaroxaban, among others) can result in AKI by causing glomerular hemorrhage and renal tubular obstruction by RBC casts. This may be a serious potential complication especially in older patients with underlying chronic kidney injury.

References:

Glassock RJ. Anticoagulant-Related Nephropathy It’s the Real McCoy. CJASN 14:935-937, 2019.

Brodsky S, Eikelboom J, Hebert LA. Anticouagulant-Related Nephropathy. J Am Soc Nephrol 29:2787-2793, 2018.

Brodsky S, Satoskar A, et al. Acute Kidney Injury During Warfarin Therapy Associated with Obstructive Tubular Red blood Cell Casts: A Report of Nine Cases.  Am J Kidney Dis 54(6):1121-6, 2009.

Brodsky S, Nadasdy T, et al. Warfarin-related nephropathy occurs in patient with and without chronic kidney disease and is associated with an increased mortality rate.  Kidney Int 80:181-189, 2011.

Wheeler DS, Giugliano RP, Rangaswami J. Anticoagulation-related nephropathy. J Thromb Haemost 14: 461-467, 2016.