March 26, 2020
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In 2018, Nickeleit et al. postulated a morphologic classification of polyomavirus nephropathy (PVN) based on pathologic features that correlate with clinical outcomes. The study defines 3 morphologic PVN classes using interstitial fibrosis and intra-renal PV load levels as statistically verified class denominators. It describes class 1 as an early PVN stage with favorable outcome, and classes 2 and 3 as having more pronounced impact on function with graft failure rates reaching 50% in class 3. The proposed PVN classification aims at improving clinico-pathologic correlation and the comparability of studies: a simple biopsy diagnosis of “PVN” no longer suffices.
Nickeleit V et al. The Banff working Group Classification of Definitive Polyomavirus Nephropathy: Morphologic Definitions and Clinical correlation. J Am Soc Nephrol 2018; 29:680-693.