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May 27, 2021

Twitter Poll (May 27, 2021)

PAS-positive

 

Answer: PAS-positive

The typical histologic features of casts seen in cases of light chain cast nephropathy show light chain restriction by immunofluorescence, are typically PAS-weak or negative in their staining, show fracturing, and will classically show an associated intratubular cellular reaction. Typically these casts will involve the distal tubules and collecting ducts and occasionally, crystal formation can occur.