Search & Filter All Posts
All Articles
(11 Results)
Twitter Poll (May 27, 2021)
Answer: D, PAS-positive The typical histologic features of casts seen in cases of light chain cast nephropathy show light chain…
Light Chain Cast Nephropathy
A 75-year-old female is found to have a creatinine of 4.0 mg/dL on a routine laboratory examination. At the hospital,…
Diagnose This (November 12, 2018)
What is your diagnosis and what do you need to prove it? …
Twitter Poll (September 6, 2018)
ANSWER: A – Thick ascending limb of the loops of the Henle THP (aka uromodulin) is an 85 -kDa glycoprotein…
Light Chain Cast Nephropathy with Congo Red Staining
This biopsy was taken from a 60-year-old African American female with a history of diabetes mellitus and hypertension, who presented…
Tubular Cast Tutorial
There is a histopathologic spectrum to the casts that can be seen in light chain cast nephropathy. A portion of…
Pushing Glass (August 22, 2017)
An 85-year-old gentleman presents to the clinic with nephrotic range proteinuria and a creatinine of 10.0 mg/dl. He reports a…
Extramedullary Hematopoiesis
This renal biopsy shows extramedullary hematopoiesis (EMH), which is the presence of hematopoietic elements (erythroid, myeloid, and/or megakaryocytic) found outside…
Amyloid Casts
The differential diagnosis of acute renal failure in patients with multiple myeloma includes light chain cast nephropathy, amyloidosis, and monoclonal…
Light Chain Cast Nephropathy
Immunofluorescence staining with kappa light chain and lambda light chain antibodies shows negative kappa in casts that are lambda positive…
Light Chain Cast Nephropathy
Atypical fractured cast that is pale on PAS stain is suggestive of light chain cast nephropathy (LCCN). Immunofluorescence examination for…