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(11 Results)![PAS-positive](https://www.arkanalabs.com/wp-content/uploads/05/27/Screen-Shot-2021-05-27-at-5.11.54-PM-432x288.png)
Twitter Poll (May 27, 2021)
Answer: D, PAS-positive The typical histologic features of casts seen in cases of light chain cast nephropathy show light chain…
![Kappa Light Chain Cast Nephropathy, teaching point, Arkana Laboratories, renal pathology](https://www.arkanalabs.com/wp-content/uploads/Figure-1-copy-17-432x288.jpg)
Light Chain Cast Nephropathy
A 75-year-old female is found to have a creatinine of 4.0 mg/dL on a routine laboratory examination. At the hospital,…
![PAS negative intratubular casts in renal biopsy at Arkana Laboratories](https://www.arkanalabs.com/wp-content/uploads/xx-copy-432x288.jpg)
Diagnose This (November 12, 2018)
What is your diagnosis and what do you need to prove it? …
![THP](https://www.arkanalabs.com/wp-content/uploads/tp2.28-12-432x288.jpg)
Twitter Poll (September 6, 2018)
ANSWER: A – Thick ascending limb of the loops of the Henle THP (aka uromodulin) is an 85 -kDa glycoprotein…
![PAS-pale, focally fractured tubular casts with associated cellular reaction](https://www.arkanalabs.com/wp-content/uploads/Fig-1-copy-46-432x288.jpg)
Light Chain Cast Nephropathy with Congo Red Staining
This biopsy was taken from a 60-year-old African American female with a history of diabetes mellitus and hypertension, who presented…
![Tubular Cast Tutorial](https://www.arkanalabs.com/wp-content/uploads/Light-chain-cast-nephropathy-432x288.jpg)
Tubular Cast Tutorial
There is a histopathologic spectrum to the casts that can be seen in light chain cast nephropathy. A portion of…
![Light Chain Cast Nephropathy](https://www.arkanalabs.com/wp-content/uploads/PAS-stain-copy-432x288.jpg)
Pushing Glass (August 22, 2017)
An 85-year-old gentleman presents to the clinic with nephrotic range proteinuria and a creatinine of 10.0 mg/dl. He reports a…
![Extramedullary Hematopoiesis](https://www.arkanalabs.com/wp-content/uploads/EMH-copy-432x288.jpg)
Extramedullary Hematopoiesis
This renal biopsy shows extramedullary hematopoiesis (EMH), which is the presence of hematopoietic elements (erythroid, myeloid, and/or megakaryocytic) found outside…
![Amyloid Casts](https://www.arkanalabs.com/wp-content/uploads/Amyloid-casts_image01-copy-432x288.jpg)
Amyloid Casts
The differential diagnosis of acute renal failure in patients with multiple myeloma includes light chain cast nephropathy, amyloidosis, and monoclonal…
![](https://www.arkanalabs.com/wp-content/uploads/Kappa-Negative-Lambda-Positive-in-Casts-1-432x288.jpg)
Light Chain Cast Nephropathy
Immunofluorescence staining with kappa light chain and lambda light chain antibodies shows negative kappa in casts that are lambda positive…
![Light Chain Cast Nephropathy](https://www.arkanalabs.com/wp-content/uploads/PAS-Pale-Fractured-Casts-copy-432x288.jpg)
Light Chain Cast Nephropathy
Atypical fractured cast that is pale on PAS stain is suggestive of light chain cast nephropathy (LCCN). Immunofluorescence examination for…