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Twitter Poll (September 6, 2018)

By Vanessa Moreno, MD

Sep 10, 2018


ANSWER: A – Thick ascending limb of the loops of the Henle

THP (aka uromodulin) is an 85 -kDa glycoprotein encoded by the UMOD gene in humans.  It’s involved in the pathogenesis of light chain cast nephropathy, urolithiasis, and tubulointerstitial nephritis, in urothelial cytoprotection against UTIs, and in mutations of the THP gene in FJHN and MCKD2.


Micanovic R, et al. Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis. J Am Soc Nephrol 2015; 26(9): 2172-2182.

Serafini-Cessi F, et al. Tamm-Horsfall glycoprotein: biology and clinical relevance. Am J Kidney Dis 2003; 42: 658-676.

Nasr SH, et al. Uromodulin storage disease. Kidney Int. 2008 Apr;73(8):971-6. 

Eckardt, et al. Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management–A KDIGO consensus report. Kidney Int. 2015 Oct;88(4):676-83.


Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.