September 10, 2018
Twitter Poll (September 6, 2018)
ANSWER: A - Thick ascending limb of the loops of the Henle
THP (aka uromodulin) is an 85 -kDa glycoprotein encoded by the UMOD gene in humans. It’s involved in the pathogenesis of light chain cast nephropathy, urolithiasis, and tubulointerstitial nephritis, in urothelial cytoprotection against UTIs, and in mutations of the THP gene in FJHN and MCKD2.
Micanovic R, et al. Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis. J Am Soc Nephrol 2015; 26(9): 2172-2182.
Serafini-Cessi F, et al. Tamm-Horsfall glycoprotein: biology and clinical relevance. Am J Kidney Dis 2003; 42: 658-676.
Nasr SH, et al. Uromodulin storage disease. Kidney Int. 2008 Apr;73(8):971-6.
Eckardt, et al. Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management--A KDIGO consensus report. Kidney Int. 2015 Oct;88(4):676-83.