Back to Blog

Tubular Cast Tutorial

Chris Larsen, MD renal pathologist at arkana laboratories
By Chris Larsen, MD

Mar 08, 2018

Tubular Cast Tutorial

There is a histopathologic spectrum to the casts that can be seen in light chain cast nephropathy. A portion of this spectrum is shown in these photomicrographs of renal biopsies stained with PAS. All three of these cases had casts with light chain restriction by immunofluorescence. Photomicrograph A shows the classic PAS-negative cast with a cellular reaction. The casts in Photomicrograph B have an elongated crystalline appearance. The casts in Photomicrograph C stain weak by PAS and have more of a granular appearance. It is important for the renal pathologist to be aware of this histopathologic spectrum though there is no known clinical significance to the variation in appearance by light microscopy.

elongated crystalline appearance, tubular casts, renal casts, casts

weak by PAS and have more of a granular appearance


Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.