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monoclonal gammopathies , arkana laboratories, art of medicine, kidney art
Art of Medicine

Art of Medicine: Proliferative Glomerulonephriits with Monoclonal Immunoglobulin Deposits

The above painting shows normal bone marrow, containing erythroid and myeloid precursors at various stages of maturation and normal trabeculae.…

Monoclonal Immunoglobulin Deposits
Art of Medicine

Art of Medicine: Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits

Small destructive B cell or plasma cell clones may be responsible for disease development. The above painting shows normal bone…

Monoclonal Gammopathies of Renal Significance
Art of Medicine

Art of Medicine: Monoclonal Gammopathies of Renal Significance

The above painting is of a bone marrow biopsy showing replacement of the hematopoietic elements with plasma cells, including atypical…


Type 1 Cryoglobulinemic Glomerulonephritis, arkana laboratories
Teaching Points

Type 1 Cryoglobulinemic Glomerulonephritis

The patient is a 75 year-old female who presents with proteinuria, a necrotic skin lesion on her lower extremity, and…

Monoclonal Gammopathy of Renal Significance, arkana laboratories, disease week, renal pathology, kidney biopsy
Disease Week

Disease Week: Monoclonal Gammopathy of Renal Significance

Disease Week: Monoclonal Gammopathy of Renal Significance Summary: Renal disease caused by parenchymal deposition of circulating monoclonal immunoglobulins (mIg)…

Kappa Light Chain Cast Nephropathy, teaching point, Arkana Laboratories, renal pathology
Teaching Points

Light Chain Cast Nephropathy

A 75-year-old female is found to have a creatinine of 4.0 mg/dL on a routine laboratory examination. At the hospital,…


Fanconi Syndrome
Art of Medicine

Art of Medicine: Fanconi Syndrome

This painting shows the transition between a proximal tubule and the thick descending limb of the loop of Henle. The…

AL-type Amyloidosis, arkana laboratories, diagnose this, renal path, kidney path, nephropath, chronic kidney disease
Diagnose This!

Diagnose This (April 1, 2019)

What is your diagnosis?     …

By L. Nich Cossey, MD
kappa light chain, diagnose this, arkana laboratories, renal pathology
By L. Nich Cossey, MD

AL-Type Amyloidosis, teaching point, arkana laboratories, renal pathology, kidney biopsy
Teaching Points

AL Amyloidosis

A 70 year-old female presents with nephrotic range proteinuria and a creatinine of 1.2. She was in her normal level…

Art of Medicine

Art of Medicine: Light Chain Proximal Tubulopathy

The painting above shows light chain proximal tubulopathy with crystals, which is one type of a monoclonal gammopathy of renal…

MGRS, Monoclonal gammopathy of renal significance, arkana laboratories, pathology of the kidney
Twitter Poll

Twitter Poll (December 7, 2018)

ANSWER: D MGRS was introduced to acknowledge a clonal plasma cell or B lymphocyte proliferation causing a renal lesion in…

By Vanessa Moreno, MD

PAS negative intratubular casts in renal biopsy at Arkana Laboratories
Diagnose This!

Diagnose This (November 12, 2018)

What is your diagnosis and what do you need to prove it?       …

By L. Nich Cossey, MD
Monoclonal Gammopathy of Renal Significance
Diagnose This!

Diagnose This! (August 6, 2018)

What is your diagnosis? This is a complicated case. The photomicrographs show a membranoproliferative pattern glomerulonephritis (MPGN) with IgG Lambda…

By L. Nich Cossey, MD
Kappa-Restricted Light Chain Deposition Disease, renal cortex
Diagnose This!

Diagnose This (July 23, 2018)

What is your diagnosis? The images show thickened tubular basement membranes on PAS stain and kappa restricted staining of the…

By L. Nich Cossey, MD