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Diagnose This (April 1, 2019)

By L. Nich Cossey, MD

Apr 01, 2019

Diagnose This!
AL-type Amyloidosis, arkana laboratories, diagnose this, renal path, kidney path, nephropath, chronic kidney disease
Camera information: Calibration= 1.000 Pixels per pixel; Capture format= 1392 x 1040, Full Frame HQ; Gamma= 0.89; Gain= 1.0 x; Exposure= 7.19 ms; Auto exposure= On; Image type= Colour; Shading= (None); Sharpening= Off; Black clip= 10; White clip= 206; Microscope information:

What is your diagnosis?

 

 

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This photomicrograph (PAS stain) shows a glomerulus with mesangial expansion by an acellular, PAS-pale, homogenous material consistent with amyloid. Further confirmation staining by Congo red (see below) shows positive staining within areas of amyloid deposition and apple-green birefringence on polarization. By immunofluorescence the amyloid deposits showed lambda light chain restriction making this an AL-type amyloidosis.

AL-type Amyloidosis stain

 

 

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Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.

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