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Neuro Notes

Congo Red Elastic Lamina

This previously healthy 30-year-old patient presented with tingling and numbness involving their extremities, followed by progressive lower extremity muscle weakness…

TTR gene
Neuro Notes

Hereditary Amyloid Neuropathy

Elderly female with amyloid neuropathy of the sural nerve. Cross-sections of the left sural nerve prepared from formalin-fixed paraffin-embedded (FFPE)…

By Kelly Mrachek, MD
Amyloid Proximal Tubulopathy
Diagnose This!

Diagnose This (August 2, 2021)

This biopsy is from a 61yo male with DM, CHF, CKD4, and an abnormal SPEP. UMOD IHC was negative. What…


ALECT2 Amyloidosis, arkana laboratories, renal pathology
Teaching Points

ALECT2 Amyloidosis

The patient is a 75-year-old Hispanic male who presents with progressively worsening kidney function and a creatinine of 1.6 mg/dl…

AL-type Amyloidosis, arkana laboratories, diagnose this, renal path, kidney path, nephropath, chronic kidney disease
Diagnose This!

Diagnose This (April 1, 2019)

What is your diagnosis?     …

By L. Nich Cossey, MD
ANCA Disease, LECT2 Amyloid, IgG4-Related Disease, AL amyloidosis, ANCA, digging deeper, Dr. Messias, Arkana Laboratories, pathology diseases
Digging Deeper

Step By Step

The biopsy is from a 65 year-old female who presented with acute renal failure and elevated creatinine up to 1.9…

By Nidia Messias, MD

IgA nephropathy in renal biopsy from Arkana Laboratories
Teaching Points

IgA nephropathy with something extra…

The biopsy is from a 61-year-old man with a history of intermittent microscopic hematuria for many years who presents with…

AL Amyloidosis
Teaching Points

Vascular-Limited AL Amyloidosis

A renal biopsy was performed on this 78 year old male with history of diabetes mellitus, hypertension and monoclonal gammopathy…

PAS-pale, focally fractured tubular casts with associated cellular reaction
Teaching Points

Light Chain Cast Nephropathy with Congo Red Staining

This biopsy was taken from a 60-year-old African American female with a history of diabetes mellitus and hypertension, who presented…


Amyloidosis, ALect2-Type, arkana laboratories, pushing glass
Pushing Glass

Pushing Glass (April 6, 2018)

A 75-year-old Hispanic male presents with a creatinine of 3. His creatinine has slowly been creeping up over the last…

glomerulus with Congo red positive mesangial staining
Teaching Points

Congo Red Stain Tutorial

Positive Congo red staining in tissue with apple-greenbirefringenceunderpolarized lightis diagnostic of the presence of amyloid fibrils. Image A shows a…

Fibrinogen Aα-chain Amyloidosis
Teaching Points

Fibrinogen Aα-chain Amyloidosis

A 65-year-old male, with no significant past medical history, presents with proteinuria and worsening renal function. The serum creatinine is…


Apolipoprotein A-IV Amyloidosis
Teaching Points

Apolipoprotein A-IV Amyloidosis

This renal biopsy from a 71-year-old female, who presented with progressively worsening renal failure, shows unremarkable glomeruli by light microscopy…

lambda light chain restricted renal amyloidosis
By L. Nich Cossey, MD
Fibrillary Glomerulopathy
Pushing Glass

Pushing Glass (August 8, 2017)

A 69-year-old man with past medical history of hypertension presents with nephrotic syndrome and 7 gm/day proteinuria. Serological studies are…

By Md Shahrier Amin, MD