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Diagnose This! (December 4, 2017)

L. Nich Cossey, MD
By L. Nich Cossey, MD

Dec 04, 2017

lambda light chain restricted renal amyloidosis
Camera information: Calibration= 1.000 Pixels per pixel; Capture format= 1392 x 1040, Full Frame HQ; Gamma= 0.99; Gain= 1.0 x; Exposure= 8.74 ms; Auto exposure= On; Image type= Colour; Shading= LM; Sharpening= Low; Black clip= 0; White clip= 231; Microscope information:

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The photomicrograph shows a glomerulus on PAS stain with mesangial accumulation of homogenous PAS-pale material consistent with amyloid. This material showed positive staining by Congo Red with apple green birefringence on polarization (see below) and lambda light chain restriction on immunofluorescence (not shown) that is consistent with an AL-type, lambda light chain restricted renal amyloidosis.

lambda light chain restricted renal amyloidosis

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