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AA Amyloidosis, glomerular crescent
Renal Review

Case 3: A Chameleon in Green

Clinical presentation The patient is a 45-year-old male with a history of IV drug use, hepatitis C, and multiple skin…

By Odia Molen, MD
Amyloidosis, AA amyloid, IV drug, proteinuria
Diagnose This!

Diagnose This (August 24, 2021)

This is the biopsy of a 32yo IV drug user who has nephrotic range proteinuria and MSSA bacteremia secondary to…

Amyloidosis, LECT-2, renal pathology, kidney biopsy, arkana laboratories
Diagnose This!

Diagnose This (December 7, 2020)

What would be your leading Dx and subtype based on the Congo red image above showing deposition predominately in the…


AL-Type Amyloidosis, teaching point, arkana laboratories, renal pathology, kidney biopsy
Teaching Points

AL Amyloidosis

A 70 year-old female presents with nephrotic range proteinuria and a creatinine of 1.2. She was in her normal level…

apolipoprotein IV (AAPOAIV) in the kidney
Twitter Poll

Twitter Poll (January 30, 2019)

ANSWER: B The medulla is the only compartment affected by AAPOAIV amyloidosis, sometimes with large amounts of amyloid. Glomeruli and…

By Vanessa Moreno, MD
ANCA Disease, LECT2 Amyloid, IgG4-Related Disease, AL amyloidosis, ANCA, digging deeper, Dr. Messias, Arkana Laboratories, pathology diseases
Digging Deeper

One little, two little, three little findings…

This biopsy came to us for evaluation of nephrotic syndrome. The patient is a Hispanic gentleman in his late 80s,…

By Nidia Messias, MD

LECT2 Amyloidosis, tubulointerstitial and vascular deposition of a PAS-pale
Teaching Points

LECT2 Amyloidosis

The renal biopsy from this 79-year-old Hispanic male shows extensive glomerular, tubulointerstitial and vascular deposition of a PAS-pale (Fig 1),…

Amyloidosis, ALect2-Type, arkana laboratories, pushing glass
Pushing Glass

Pushing Glass (April 6, 2018)

A 75-year-old Hispanic male presents with a creatinine of 3. His creatinine has slowly been creeping up over the last…

glomerulus with Congo red positive mesangial staining
Teaching Points

Congo Red Stain Tutorial

Positive Congo red staining in tissue with apple-greenbirefringenceunderpolarized lightis diagnostic of the presence of amyloid fibrils. Image A shows a…


Fibrinogen Aα-chain Amyloidosis
Teaching Points

Fibrinogen Aα-chain Amyloidosis

A 65-year-old male, with no significant past medical history, presents with proteinuria and worsening renal function. The serum creatinine is…

Apolipoprotein A-IV Amyloidosis
Teaching Points

Apolipoprotein A-IV Amyloidosis

This renal biopsy from a 71-year-old female, who presented with progressively worsening renal failure, shows unremarkable glomeruli by light microscopy…

lambda light chain restricted renal amyloidosis
By L. Nich Cossey, MD

Amyloid Fibril Deposits
Twitter Poll

Twitter Poll (September 12, 2017)

Answer: C Amyloid fibrils typically measure 8-12 nm (answer C). The deposits seen in Immunotactoid glomerulopathy are composed by tubules…

By Vanessa Moreno, MD
Amyloidosis
Pushing Glass

Pushing Glass (July 25, 2017)

The patient is a 64-year-old female who presents with 4.5 grams of proteinuria, hematuria, and a creatinine of 1.5. She…