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Diagnose This 4/29/2024
What would be your leading Dx and subtype based on the Congo red image above showing deposition predominately in the…
![AA Amyloidosis, glomerular crescent](https://www.arkanalabs.com/wp-content/uploads/2022/10/Renal-Review-HZ-432x288.png)
Case 3: A Chameleon in Green
Clinical presentation The patient is a 45-year-old male with a history of IV drug use, hepatitis C, and multiple skin…
![Amyloidosis, AA amyloid, IV drug, proteinuria](https://www.arkanalabs.com/wp-content/uploads/08/24/08.10-432x288.png)
Diagnose This (August 24, 2021)
This is the biopsy of a 32yo IV drug user who has nephrotic range proteinuria and MSSA bacteremia secondary to…
![Amyloidosis, LECT-2, renal pathology, kidney biopsy, arkana laboratories](https://www.arkanalabs.com/wp-content/uploads/12/08/Dx-This-432x288.jpg)
Diagnose This (December 7, 2020)
What would be your leading Dx and subtype based on the Congo red image above showing deposition predominately in the…
![AL-Type Amyloidosis, teaching point, arkana laboratories, renal pathology, kidney biopsy](https://www.arkanalabs.com/wp-content/uploads/Figure-1-copy-10-432x288.jpg)
AL Amyloidosis
A 70 year-old female presents with nephrotic range proteinuria and a creatinine of 1.2. She was in her normal level…
![apolipoprotein IV (AAPOAIV) in the kidney](https://www.arkanalabs.com/wp-content/uploads/2019/02/apolipoprotein-IV-AAPOAIV-in-the-kidney-432x288.png)
Twitter Poll (January 30, 2019)
ANSWER: B The medulla is the only compartment affected by AAPOAIV amyloidosis, sometimes with large amounts of amyloid. Glomeruli and…
![ANCA Disease, LECT2 Amyloid, IgG4-Related Disease, AL amyloidosis, ANCA, digging deeper, Dr. Messias, Arkana Laboratories, pathology diseases](https://www.arkanalabs.com/wp-content/uploads/DiggingDeeper-432x288.jpg)
One little, two little, three little findings…
This biopsy came to us for evaluation of nephrotic syndrome. The patient is a Hispanic gentleman in his late 80s,…
![LECT2 Amyloidosis, tubulointerstitial and vascular deposition of a PAS-pale](https://www.arkanalabs.com/wp-content/uploads/Fig-1-copy-45-432x288.jpg)
LECT2 Amyloidosis
The renal biopsy from this 79-year-old Hispanic male shows extensive glomerular, tubulointerstitial and vascular deposition of a PAS-pale (Fig 1),…
![Amyloidosis, ALect2-Type, arkana laboratories, pushing glass](https://www.arkanalabs.com/wp-content/uploads/Low-power-trichrome-stain-copy-432x288.jpg)
Pushing Glass (April 6, 2018)
A 75-year-old Hispanic male presents with a creatinine of 3. His creatinine has slowly been creeping up over the last…
![glomerulus with Congo red positive mesangial staining](https://www.arkanalabs.com/wp-content/uploads/5327-10-1-432x288.jpg)
Congo Red Stain Tutorial
Congo Red Stain Tutorial: What does it show? Positive Congo red staining in tissue with apple-greenbirefringenceunderpolarized lightis diagnostic of the…
![Fibrinogen Aα-chain Amyloidosis](https://www.arkanalabs.com/wp-content/uploads/Fig-1-copy-30-432x288.jpg)
Fibrinogen Aα-chain Amyloidosis
A 65-year-old male, with no significant past medical history, presents with proteinuria and worsening renal function. The serum creatinine is…
![Apolipoprotein A-IV Amyloidosis](https://www.arkanalabs.com/wp-content/uploads/Fig-1-copy-29-432x288.jpg)
Apolipoprotein A-IV Amyloidosis
This renal biopsy from a 71-year-old female, who presented with progressively worsening renal failure, shows unremarkable glomeruli by light microscopy…
![Amyloid Fibril Deposits](https://www.arkanalabs.com/wp-content/uploads/tp9.12-432x288.jpg)
Twitter Poll (September 12, 2017)
Answer: C Amyloid fibrils typically measure 8-12 nm (answer C). The deposits seen in Immunotactoid glomerulopathy are composed by tubules…
![Amyloidosis](https://www.arkanalabs.com/wp-content/uploads/1-Low-power-trichrome-copy-432x288.jpg)
Pushing Glass (July 25, 2017)
The patient is a 64-year-old female who presents with 4.5 grams of proteinuria, hematuria, and a creatinine of 1.5. She…