The medulla is the only compartment affected by AAPOAIV amyloidosis, sometimes with large amounts of amyloid. Glomeruli and vessels are spared and not affected by this type of amyloid.
AAPOAIV Amyloidosis is a systemic amyloidosis reported from wild-type apolipoprotein AIV. When the kidney is involved the patient presents with gradual loss of renal function and proteinuria. It may also have cardiac involvement.
Sethi S, Theis JD, Shiller SM, et al. Medullary amyloidosis associated with apolipoprotein A-IV deposition. Kidney Int 81: 201–206, 2012.
Dasari S, Amin S, Kurtin P, et al. Clinical, biopsy, and mass spectrometry characteristics of renal apolipoprotein A-IV amyloidosis. Kidney Int 90: 658-64, 2016.
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