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March 22, 2018

Congo Red Stain Tutorial

glomerulus with Congo red positive mesangial staining

Positive Congo red staining in tissue with apple-green birefringence under polarized light is diagnostic of the presence of amyloid fibrils. Image A shows a glomerulus with Congo red positive mesangial staining while image B shows a renal biopsy with diabetic nephropathy that is negative for Congo red. Accurate interpretation of this stain hinges upon proper optimization so that there is elimination of nonspecific background staining.

diabetic nephropathy that is negative for Congo red