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Pushing Glass (July 25, 2017)

Michael Kuperman, MD renal pathologist at arkana laboratories
By Michael Kuperman, MD

Jul 25, 2017


The patient is a 64-year-old female who presents with 4.5 grams of proteinuria, hematuria, and a creatinine of 1.5. She has a history of hypertension and coronary artery disease.

What is the best diagnosis?

A. Arterionephrosclerosis
B. Focal Segmental Glomerulosclerosis
C. Amyloidosis
D. Fibrillary Glomerulonephritis

The best answer is C: Amyloidosis.
The biopsy, at first glance, looks like a subcapsular scar with diffuse global glomerulosclerosis. In this setting, arterionephrosclerosis would provide a good explanation for this distribution of fibrosis especially with the severe arteriosclerosis seen in the vessel. FSGS is also a consideration and can produce segmental scars with extensive global glomerulosclerosis. However, the presence of Congo red positivity and lambda light chain restriction within the glomeruli and vessels is diagnostic for amyloidosis, AL type. Fibrillary glomerulonephritis would not affect the vessels and is Congo red negative.


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