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Diagnose This (November 2, 2020)
What is this finding? In a young male patient with hematuria and hearing loss, what would be your top diagnosis?…
Twitter Poll (September 16, 2020)
Answer: C Fibrillary glomerulonephritis is a rare disease affecting less than 1% of all native kidney biopsies and is due…
Disease Week: Alport Syndrome
Monday In 1927, Dr. Cecil Alport published a series on “hereditary familial congenital haemorrhagic nephritis” where he described its association…
Art of Medicine: ANCA-Associated Glomerulonephritis
The painting above shows a crescentic glomerulonephritis and necrotizing arteritis. A mixed interstitial inflammatory infiltrate is shown in the top…
KDIGO Connections: Secondary IgA Nephropathy
Learn about secondary IgA nephropathy. IgA depositions has been associated with many conditions including infections, cirrhosis, and others.
Digging Deeper, or How We Never Quit
We received the biopsy from a 25-year-old female who presented for evaluation of nephrotic range proteinuria. Lab evaluation reveals a…
Lupus Nephritis (Class IV)
A 20-year-old female presents with hematuria, proteinuria, and a creatinine of 1.2 mg/dl. Serologies for ANA are positive. Complement levels…
KDIGO Connections: Crescentic IgA Nephropathy
How do you treat Crescentic IgA Nephropathy? Learn how to define which stage the patient is in and what treatments…
Diagnose This (January 21, 2019)
A limited sample showed this lesion and negative staining on paraffin-retrieved IF tissue. What is your diagnosis? …
Digging Deeper – Here, There, and Everywhere
This biopsy came from an elderly gentleman in his 80s, who presented with acute renal failure. His serum creatinine had…
Infection-Associated Glomerulonephritis
A 60-year-old male presents with a painful left hip, hematuria, and a creatinine of 1.5 mg/dl. He was recently hospitalized…
IgA nephropathy with something extra…
The biopsy is from a 61-year-old man with a history of intermittent microscopic hematuria for many years who presents with…
DNAJB9 helps uncover dual pathology…
This case illustrates the utility of immunohistochemical staining for DNAJB9, a recently described biomarker for fibrillary glomerulopathy (see reference). The…
IgA Nephropathy Oxford Scoring
TheIgA nephropathy Oxford Classification was first published in 2009 by a working group of nephrologists and renal pathologists representing the…
