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Diagnose This (November 2, 2020)
What is this finding? In a young male patient with hematuria and hearing loss, what would be your top diagnosis?…
Twitter Poll (September 16, 2020)
Answer: C Fibrillary glomerulonephritis is a rare disease affecting less than 1% of all native kidney biopsies and is due…
Disease Week: Alport Syndrome
Monday In 1927, Dr. Cecil Alport published a series on “hereditary familial congenital haemorrhagic nephritis” where he described its association…
Art of Medicine: ANCA-Associated Glomerulonephritis
The painting above shows a crescentic glomerulonephritis and necrotizing arteritis. A mixed interstitial inflammatory infiltrate is shown in the top…
Digging Deeper, or How We Never Quit
We received the biopsy from a 25-year-old female who presented for evaluation of nephrotic range proteinuria. Lab evaluation reveals a…
Lupus Nephritis (Class IV)
A 20-year-old female presents with hematuria, proteinuria, and a creatinine of 1.2 mg/dl. Serologies for ANA are positive. Complement levels…
KDIGO Connections: Crescentic IgA Nephropathy
How do you treat crescentic IgA nephropathy?
Diagnose This (January 21, 2019)
A limited sample showed this lesion and negative staining on paraffin-retrieved IF tissue. What is your diagnosis? …
Digging Deeper – Here, There, and Everywhere
This biopsy came from an elderly gentleman in his 80s, who presented with acute renal failure. His serum creatinine had…
Infection-Associated Glomerulonephritis
A 60-year-old male presents with a painful left hip, hematuria, and a creatinine of 1.5 mg/dl. He was recently hospitalized…
IgA nephropathy with something extra…
The biopsy is from a 61-year-old man with a history of intermittent microscopic hematuria for many years who presents with…
DNAJB9 helps uncover dual pathology…
This case illustrates the utility of immunohistochemical staining for DNAJB9, a recently described biomarker for fibrillary glomerulopathy (see reference). The…
IgA Nephropathy Oxford Scoring
TheIgA nephropathy Oxford Classification was first published in 2009 by a working group of nephrologists and renal pathologists representing the…
