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Alport Syndrome, Arkana Laboratories, diagnose this, renal pathology, kindey path, kidney disease
Diagnose This!

Diagnose This (November 2, 2020)

What is this finding? In a young male patient with hematuria and hearing loss, what would be your top diagnosis?…

Fibrillary glomerulonephritis, arkana laboratories, twitter poll
Twitter Poll

Twitter Poll (September 16, 2020)

Answer: C Fibrillary glomerulonephritis is a rare disease affecting less than 1% of all native kidney biopsies and is due…

alport syndrome, disease week, arkana laboratories
Disease Week

Disease Week: Alport Syndrome

Monday In 1927, Dr. Cecil Alport published a series on “hereditary familial congenital haemorrhagic nephritis” where he described its association…


anca-associated-glomerulonephritis, art of medicine
Art of Medicine

Art of Medicine: ANCA-Associated Glomerulonephritis

The painting above shows a crescentic glomerulonephritis and necrotizing arteritis. A mixed interstitial inflammatory infiltrate is shown in the top…

Alport Syndrome, Digging Deeper, Arkana laboratories, renal pathology, kidney pathology, nephropathology
Digging Deeper

Digging Deeper, or How We Never Quit

We received the biopsy from a 25-year-old female who presented for evaluation of nephrotic range proteinuria. Lab evaluation reveals a…

Nidia Messias, MD
By Nidia Messias, MD

Lupus Nephritis, arkana laboratories, teaching point, nephropathology
Teaching Points

Lupus Nephritis (Class IV)

A 20-year-old female presents with hematuria, proteinuria, and a creatinine of 1.2 mg/dl. Serologies for ANA are positive. Complement levels…

crescentic IgA nephropathy, KDIGO Connections, arkana laboratories, renal pathology, kidney pathology, nephropathology
KDIGO Connections

KDIGO Connections: Crescentic IgA Nephropathy

How do you treat crescentic IgA nephropathy?    

GBM, glomerular basement membranes, diagnose this, arkana laboratories
Diagnose This!

Diagnose This (January 28, 2019)

What is your diagnosis?     …

L. Nich Cossey, MD
By L. Nich Cossey, MD

Anti-GBM, renal pathology , diagnose this!, arkana laboratories
Diagnose This!

Diagnose This (January 21, 2019)

A limited sample showed this lesion and negative staining on paraffin-retrieved IF tissue. What is your diagnosis? …

L. Nich Cossey, MD
By L. Nich Cossey, MD
ANCA Disease, LECT2 Amyloid, IgG4-Related Disease, AL amyloidosis, ANCA, digging deeper, Dr. Messias, Arkana Laboratories, pathology diseases
Digging Deeper

Digging Deeper – Here, There, and Everywhere

This biopsy came from an elderly gentleman in his 80s, who presented with acute renal failure. His serum creatinine had…

Nidia Messias, MD
By Nidia Messias, MD
Infection-Associated Glomerulonephritis
Teaching Points

Infection-Associated Glomerulonephritis

A 60-year-old male presents with a painful left hip, hematuria, and a creatinine of 1.5 mg/dl. He was recently hospitalized…


IgA nephropathy in renal biopsy from Arkana Laboratories
Teaching Points

IgA nephropathy with something extra…

The biopsy is from a 61-year-old man with a history of intermittent microscopic hematuria for many years who presents with…

DNAJB9 Uncovers Dual Pathology
Teaching Points

DNAJB9 helps uncover dual pathology…

This case illustrates the utility of immunohistochemical staining for DNAJB9, a recently described biomarker for fibrillary glomerulopathy (see reference). The…

IgA Nephropathy Oxford classification and scoring
Teaching Points

IgA Nephropathy Oxford Scoring

TheIgA nephropathy Oxford Classification was first published in 2009 by a working group of nephrologists and renal pathologists representing the…