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Fibrillary Glomerulopathy, Diagnose This!, Arkana Laboratories, pathology, nephropathology, renal pathology
Diagnose This!

Diagnose This (August 3, 2020)

What is your leading diagnosis when seeing this interesting IgG staining pattern by IF? …

Unresolved etiologies, Throwback Thursday, Dr. Fred Silva, Arkana Laboratories

Unresolved Etiologies: When the Clinical Acumen Takes Place

Dr. Silva comments on several diagnostic dilemmas where the pathology pattern leads to a plethora of possibilities.

Fred Silva, MD renal pathologist at arkana laboratories
By Dr. Fred Silva
KDIGO Connections

KDIGO Connections: MGRS

KDIGO offers some future directions for studying MGRS lesions.  

Monoclonal Gammopathies of Renal Significance
Art of Medicine

Art of Medicine: Monoclonal Gammopathies of Renal Significance

Monoclonal Gammopathies of Renal Significance The above painting is of a bone marrow biopsy showing replacement of the hematopoietic elements…

Type 1 Cryoglobulinemic Glomerulonephritis, arkana laboratories
Teaching Points

Type 1 Cryoglobulinemic Glomerulonephritis

The patient is a 75 year-old female who presents with proteinuria, a necrotic skin lesion on her lower extremity, and…

Membranoproliferative GN, monoclonal gammopathy, arkana laboratories, twitter poll, renal pathology
Twitter Poll

Twitter Poll (July 10, 2019)

Answer: True About 5-10% of the patients with monoclonal gammopathy and findings consistent with C3GN by standard IF (on frozen…

By Vanessa Moreno, MD

Monoclonal Gammopathy of Renal Significance, arkana laboratories, disease week, renal pathology, kidney biopsy
Disease Week

Disease Week: Monoclonal Gammopathy of Renal Significance

Disease Week: Monoclonal Gammopathy of Renal Significance Summary: Renal disease caused by parenchymal deposition of circulating monoclonal immunoglobulins (mIg)…

Kappa Light Chain Cast Nephropathy, teaching point, Arkana Laboratories, renal pathology
Teaching Points

Light Chain Cast Nephropathy

A 75-year-old female is found to have a creatinine of 4.0 mg/dL on a routine laboratory examination. At the hospital,…

AL-Type Amyloidosis, teaching point, arkana laboratories, renal pathology, kidney biopsy
Teaching Points

AL Amyloidosis

A 70 year-old female presents with nephrotic range proteinuria and a creatinine of 1.2. She was in her normal level…

Art of Medicine

Art of Medicine: Light Chain Proximal Tubulopathy

The painting above shows light chain proximal tubulopathy with crystals, which is one type of a monoclonal gammopathy of renal…

PAS negative intratubular casts in renal biopsy at Arkana Laboratories
Diagnose This!

Diagnose This (November 12, 2018)

What is your diagnosis and what do you need to prove it?       …

By L. Nich Cossey, MD
light chain deposition disease, pushing glass, arkana laboratories, kidney pathology
Pushing Glass

Pushing Glass (June 22, 2018)

The patient is an 80 year-old male who presents with fatigue and a creatinine of 6.5 mg/dl. He was in…

mild endocapillary hypercellularity with rare double contour formation of the capillary loops, Proliferative Glomerulonephritis with Monoclonal IgG Deposits
Teaching Points

Proliferative Glomerulonephritis with Monoclonal IgG Deposits

This biopsy was performed on an 81-year-male, status post renal transplant, who presented with increased creatinine (2.3 mg/dl) and microscopic…

Tubular Cast Tutorial
Teaching Points

Tubular Cast Tutorial

There is a histopathologic spectrum to the casts that can be seen in light chain cast nephropathy. A portion of…

Light Chain Proximal Tubulopathy
Teaching Points

Light Chain Proximal Tubulopathy

Light chain proximal tubulopathy (LCPT) is a disease characterized by the renal biopsy finding of cytoplasmic light chain restriction within…