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Diagnose This (August 3, 2020)
What is your leading diagnosis when seeing this interesting IgG staining pattern by IF? …
Unresolved Etiologies: When the Clinical Acumen Takes Place
Dr. Silva comments on several diagnostic dilemmas where the pathology pattern leads to a plethora of possibilities.
KDIGO Connections: MGRS
KDIGO offers some future directions for studying MGRS lesions.
Art of Medicine: Monoclonal Gammopathies of Renal Significance
Monoclonal Gammopathies of Renal Significance The above painting is of a bone marrow biopsy showing replacement of the hematopoietic elements…
Type 1 Cryoglobulinemic Glomerulonephritis
The patient is a 75 year-old female who presents with proteinuria, a necrotic skin lesion on her lower extremity, and…
Twitter Poll (July 10, 2019)
Answer: True About 5-10% of the patients with monoclonal gammopathy and findings consistent with C3GN by standard IF (on frozen…
Disease Week: Monoclonal Gammopathy of Renal Significance
Disease Week: Monoclonal Gammopathy of Renal Significance Summary: Renal disease caused by parenchymal deposition of circulating monoclonal immunoglobulins (mIg)…
Light Chain Cast Nephropathy
A 75-year-old female is found to have a creatinine of 4.0 mg/dL on a routine laboratory examination. At the hospital,…
AL Amyloidosis
A 70 year-old female presents with nephrotic range proteinuria and a creatinine of 1.2. She was in her normal level…
Art of Medicine: Light Chain Proximal Tubulopathy
The painting above shows light chain proximal tubulopathy with crystals, which is one type of a monoclonal gammopathy of renal…
Diagnose This (November 12, 2018)
What is your diagnosis and what do you need to prove it? …
Pushing Glass (June 22, 2018)
The patient is an 80 year-old male who presents with fatigue and a creatinine of 6.5 mg/dl. He was in…
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
This biopsy was performed on an 81-year-male, status post renal transplant, who presented with increased creatinine (2.3 mg/dl) and microscopic…
Tubular Cast Tutorial
There is a histopathologic spectrum to the casts that can be seen in light chain cast nephropathy. A portion of…
Light Chain Proximal Tubulopathy
Light chain proximal tubulopathy (LCPT) is a disease characterized by the renal biopsy finding of cytoplasmic light chain restriction within…