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July 23, 2018

Diagnose This (July 23, 2018)

Kappa-Restricted Light Chain Deposition Disease, renal cortex

What is your diagnosis?

Kappa-Restricted Light Chain Deposition Disease, EM renal biopsy image

Kappa IF Cortex Kappa-Restricted Light Chain Deposition Disease

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The images show thickened tubular basement membranes on PAS stain and kappa restricted staining of the tubular basement membranes by immunofluorescence. Additionally, by electron microscopy, punctate, powdery, electron-dense deposits are present along the tubular basement membranes that are consistent with light chain type deposits. These findings are consistent with kappa-restricted light chain deposition disease.