July 23, 2018
Diagnose This (July 23, 2018)

- Published: July 23, 2018
- By: L. Nich Cossey, MD
- Tags: Light chain deposition disease, Monoclonal gammopathy of renal significance, Proteinuria
What is your diagnosis?
The images show thickened tubular basement membranes on PAS stain and kappa restricted staining of the tubular basement membranes by immunofluorescence. Additionally, by electron microscopy, punctate, powdery, electron dense deposits are present along the tubular basement membranes that are consistent with light chain type deposits. These findings are consistent with kappa-restricted light chain deposition disease.