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Kappa-Restricted Light Chain Deposition Disease, renal cortex
Diagnose This!

Diagnose This (July 23, 2018)

What is your diagnosis? The images show thickened tubular basement membranes on PAS stain and kappa restricted staining of the…

L. Nich Cossey, MD
By L. Nich Cossey, MD
Peritubular Giant Cells, giant cell reaction surrounding many of the tubules
Teaching Points

Peritubular Giant Cells

When giant cells surround tubules This renal biopsy was taken from a young woman with elevated serum creatinine (4.3 mg/dL),…

Light Chain Deposition Disease
Teaching Points

Light Chain Deposition Disease

The immunofluorescence in cases of monoclonal immunoglobulin deposition disease is characterized by linear tubular basement membrane staining. In these cases,…


light chain deposition disease, pushing glass, arkana laboratories, kidney pathology
Pushing Glass

Pushing Glass (June 22, 2018)

The patient is an 80 year-old male who presents with fatigue and a creatinine of 6.5 mg/dl. He was in…

Pushing Glass

Pushing Glass (January 26, 2018)

An otherwise asymptomatic 65-year-old man presents for medical evaluation after 15 years of not seeing a physician. He was noted…

Md Shahrier Amin, MD
By Md Shahrier Amin, MD
Lambda Light Chain Restriction
L. Nich Cossey, MD
By L. Nich Cossey, MD

renal cortex from renal biopsy showing Light Chain Deposition Disease
Teaching Points

Light Chain Deposition Disease

An elderly patient presents to nephrology for a rising creatinine. Baseline creatinine was 2.1 mg/dl six weeks prior but is…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD
Light Chain Deposition Disease
Teaching Points

Light Chain Deposition Disease and Light Chain Proximal Tubulopathy

An elderly but previously healthy patient presents with weakness and fatigue and was found to have a creatinine of 3.0…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD
light chain deposition disease
Diagnose This!

Diagnose This! (July 3, 2017)

Whats your diagnosis?   …

L. Nich Cossey, MD
By L. Nich Cossey, MD