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Diagnose This! (November 13, 2017)

L. Nich Cossey, MD
By L. Nich Cossey, MD

Nov 13, 2017

Lambda Light Chain Restriction

What is your diagnosis?

 

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This photomicrograph shows extensive, granular, PAS-positive material within the interstitium and tubular basement membranes and is consistent with light chain type deposits. Light chain deposition disease is typically thought of as a disease affecting the glomeruli and tubular basement membranes, however, some cases can show extensive light chain deposits that spill into the vasculature and interstitium as seen here. In this case, lambda light chain restriction was seen in these deposits and they were Congo red negative (not shown). By electron microscopy, punctate, powdery light chain type deposits were seen frequently (see photo below).

Lambda Light Chain Restriction, light chain deposits

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Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.