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Tubular Cast Tutorial
There is a histopathologic spectrum to the casts that can be seen in light chain cast nephropathy. A portion of…
Pushing Glass (August 22, 2017)
An 85-year-old gentleman presents to the clinic with nephrotic range proteinuria and a creatinine of 10.0 mg/dl. He reports a…
Extramedullary Hematopoiesis
This renal biopsy shows extramedullary hematopoiesis (EMH), which is the presence of hematopoietic elements (erythroid, myeloid, and/or megakaryocytic) found outside…
Amyloid Casts
The differential diagnosis of acute renal failure in patients with multiple myeloma includes light chain cast nephropathy, amyloidosis, and monoclonal…
Light Chain Cast Nephropathy
Immunofluorescence staining with kappa light chain and lambda light chain antibodies shows negative kappa in casts that are lambda positive…
Light Chain Cast Nephropathy
Atypical fractured cast that is pale on PAS stain is suggestive of light chain cast nephropathy (LCCN). Immunofluorescence examination for…