The cells of Goormaghtigh, AKA extraglomerular mesangial cells, lacis cells or Polkissen cells, are part of the juxtraglomerular apparatus. Ultrastructurally, these cells resemble mesangial cells.
The lacis cells function as a physiologic liaison between the macula densa and arteriolar smooth muscle cells and the arteriolar granular myoepithelioid cells. They play an important role in renal autoregulation of blood flow to the kidney and regulation of systemic blood pressure through the renin-angiotensin system.
Eknoyan G, Rubens R, Lameire R. The juxtaglomerular apparatus of Norbert Goormaghtigh – a critical appraisal. Nephrol Dial Transplant 2009; 24:3876-81.
Christensen JA, Bohle A Mikeler E, Taugner R.”Renin-positive granulated Goormaghtigh cells. Immunohistochemical and electron-microscopic studies on biopsies from patients with pseudo-Bartter syndrome”. Cell and Tissue Research 1989; 255(1):149–53
Barajas L. anatomy of the juxtaglomerular apparatus. Am J Physiol 1979; 237:F333.
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