Exostosin is an antigen that was recently identified out of a cohort of Phospholipase A2 Receptor (PLA2R) and Thrombospondin Type-1 Domain-Containing 7A (THSD7A) negative cases of Membranous GN. Results showed that EXT1/2 positive cases were associated with autoimmune disease, including systemic lupus erythematosus (see reference).
Sethi S, Madden BJ, Debiec H, et al. Exostosin 1/Exostosin 2-Associated Membranous Nephropathy. J Am Soc Nephrol 2019; 30(6): 1123-1136.
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