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Twitter Poll (October 14, 2020)

By Joel Murphy, MD

Oct 15, 2020

Exostosin, arkana laboratories, autoimmune diseases, renal pathology

Answer: D

Exostosin is an antigen that was recently identified out of a cohort of Phospholipase A2 Receptor (PLA2R) and Thrombospondin Type-1 Domain-Containing 7A (THSD7A) negative cases of Membranous GN. Results showed that EXT1/2 positive cases were associated with autoimmune disease, including systemic lupus erythematosus (see reference).



Sethi S, Madden BJ, Debiec H, et al. Exostosin 1/Exostosin 2-Associated Membranous Nephropathy. J Am Soc Nephrol 2019; 30(6): 1123-1136.



Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.