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Diagnose This!

Diagnose This 4/15/2024

Based on the image provided, what would be your leading diagnosis with C3-dominant immune-complex deposition? The light microscopic image depicts…

Diagnose This!

Diagnose This 4/1/2024

What is this finding and what is the significance in the transplant setting?   The light microscopic image depicts an…

Diagnose This!

Diagnose This 3/18/2024

What is at the top of your differential in a patient with a positive SPEP (IgG kappa) and the immunofluorescence…

Diagnose This!

Diagnose This 3/11/2024

What is your diagnosis in a patient with nephrotic syndrome? The electron photomicrograph demonstrates frequent subepithelial deposits along the glomerular…

Diagnose This!

Diagnose This 3/4/2024

The ultrastructural abnormalities present in the image are suspicious for what underlying disease?   The electron photomicrograph demonstrates two abnormal…

Diagnose This!

Diagnose This 2/26/2024

What is your diagnosis based on the EM image provided? The electron microscopy image provided is that of portions of…

Diagnose This!

Diagnose This 2/19/2024

What is your leading diagnosis when seeing this particular IgG staining pattern?     Answer: Fibrillary Glomerulopathy The immunofluorescence shows…

Diagnose This!

Diagnose This 2/12/2024

What is your diagnosis?   The light microscopic image depicts a renal transplant biopsy with multiple histiocytes containing intracytoplasmic, targetoid…

Diagnose This!

Diagnose This 2/5/2024

What is your diagnosis in this transplant biopsy given the features present?   Answer: Chronic active antibody-mediated rejection The features…

Diagnose This!

Diagnose This 1/29/2024

What stain would you order to clinch the diagnosis in this transplant patient with AKI?   A CMV stain is…

Diagnose This!

Diagnosis This 1/15/2024

What considerations should be included in your differential diagnosis given the provided histologic finding? The image of a Jones silver…

Hepatic Glomerulosclerosis
Diagnose This!

Diagnose This! (January 9, 2023)

This is the biopsy of a 45 yo with alcoholic cirrhosis, bacteremia, hematuria, proteinuria and AKI. IF shows IgA (3+),…

The biopsy shows glomerular capillary wall double contouring, segmental glomerular microaneurisms and hyalinosis. These findings are typical of anti-VEGF therapy-induced glomerular microangiopathy.
Diagnose This!

Diagnose This (October 10, 2022)

This is the biopsy of a 47-year-old female with cervical cancer, on anti-VEGF therapy, with proteinuria and normal renal function.…

Diagnose This!

Diagnose This (September 26, 2022)

This is the biopsy from a 73-year-old with AKI and normal bone marrow biopsy done for investigation of anemia and…

NPHP1-related nephronophthisis
Diagnose This!

Diagnose This (September 19, 2022)

In a 26-year-old obese Black female with no significant PMH and elevated creatinine, what is your top diagnosis?    …