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Microcystic Tubular Dilatation
Teaching Points

Microcystic Tubular Dilatation

Microcystic dilatation of tubules is a non-specific morphologic finding associated with various diseases, including obstructive nephropathy, HIV-associated nephropathy (HIVAN), congenital…

Congenital Nephrotic Syndrome
Teaching Points

Congenital Nephrotic Syndrome

The biopsy from this 5-year-old male with nephrotic syndrome shows immature glomeruli without segmental glomerulosclerosis (Fig 1), associated with focal…

APOL1 risk alleles, IgA and APOL1-Associated Nephropathy
Teaching Points

IgA and APOL1

The presence of two APOL1 risk alleles, which predominantly affects population of recent African ancestry, confers up to 29x increased…