What conditions would be in your differential diagnosis for this finding? (Hint: large glomerulus)

 

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Answer: The image demonstrates marked glomerular enlargement, also known as glomerulomegaly. While this finding is non-specific, it indicates the presence of glomerular hyperfiltration and is typically associated with proteinuria. Clinical settings in which glomerulomegaly has been identified include obesity, premature birth, obstructive sleep apnea, sickle cell disease, cystic fibrosis, oligomeganephronia, and pulmonary hypertension.