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Global Glomerulosclerosis: Obsolescent Pattern

T. David Bourne, MD renal pathologist and neuropathologist at arkana laboratories
By David Bourne, MD

Aug 09, 2017

Obsolescent Pattern in Glomerulosclerosis

The image shows two globally sclerotic glomeruli exhibiting the so-called “obsolescent” pattern of glomerular sclerosis. The two key histologic features in this pattern are the shrunken and retracted glomerular capillary tuft (arrowhead) and the fibrous matrix which replaces Bowman’s space (arrow). This pattern of sclerosis is thought to result from reduced glomerular perfusion secondary to arteriosclerosis of small renal arteries. In contrast, the so-called “solidified” pattern of glomerular sclerosis (not shown), in which the entire remnant glomerulus is replaced by fibrous matrix, shows the strongest association with underlying APOL1-mediated kidney disease risk variants in the setting of chronic kidney disease.


Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.