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(NCAM1) Neural Cell Adhesion Molecule 1 Is A Novel Autoantigen In Membranous Lupus Nephritis

By Dr. Rebecca May

Jan 05, 2022

Membranous nephropathy is a leading cause of nephrotic syndrome. On renal biopsy, immunofluorescence shows granular capillary loop deposits, and holes are seen in the capillary loops on silver stain. Electron microscopy shows subepithelial immune complex deposits. Membranous glomerulopathy can be seen in association with autoimmune diseases including lupus. The most common antigen seen in membranous lupus nephritis is EXT1/2. This study identified a new target antigen, NCAM1, which was present in 6.6% of membranous lupus nephritis cases. Few cases of NCAM1 membranous were seen in patients with non-lupus autoimmune disease. NCAM1 can also be detected in the serum of these patients. Approximately 40% of patients had neuropsychiatric disease, including seizures and cerebritis. Clinical outcomes for these patients are still unknown.

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