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EM image of Glomerular Basement Membrane With A Reticular Appearance And Occasional "Craters"
eyeSCANdy

Glomerular Basement Membrane With A Reticular Appearance And Occasional “Craters”

This acellular scanning EM from a biopsy with membranous lupus nephritis shows glomerular basement membrane (large arrow) with a reticular…

Subepithelial Immune Deposits
eyeSCANdy

Subepithelial Immune Deposits Carpeting the GBM Surface

This acellular scanning EM from a biopsy with membranous lupus nephritis shows subepithelial immune deposits (not extracted) carpeting the GBM…

Membranous Nephropathy, Lipoic Acid in NELL1-Associated Membranous Nephropathy, SARS-CoV-2, biopsy, TGFBR3, crystalline nephropathies, Renal Intratubular Casts, viral-like inclusions, Covid-19, Anti-Brush Border Antibody Disease, MGMID, renal pathology, kidney research
Podcast

Transforming Growth Factor Beta Receptor 3 (TGFBR3)-Associated Membranous Nephropathy

Approximately half of lupus patients have kidney disease, including membranous glomerulopathy. On renal biopsy, immunofluorescence shows granular capillary loop deposits,…

By Dr. Rebecca May

Membranous Nephropathy, Lipoic Acid in NELL1-Associated Membranous Nephropathy, SARS-CoV-2, biopsy, TGFBR3, crystalline nephropathies, Renal Intratubular Casts, viral-like inclusions, Covid-19, Anti-Brush Border Antibody Disease, MGMID, renal pathology, kidney research
Podcast

(NCAM1) Neural Cell Adhesion Molecule 1 Is A Novel Autoantigen In Membranous Lupus Nephritis

Membranous nephropathy is a leading cause of nephrotic syndrome. On renal biopsy, immunofluorescence shows granular capillary loop deposits, and holes…

By Dr. Rebecca May
Disease Week

Disease Week: Lupus Nephritis

Monday: Day #1, Tweetorial #1: Welcome to a #DiseaseWeek highlighting lupus nephritis from @arkanalabs. Well present some daily Tweetorials to…

Membranous Nephropathy, Lipoic Acid in NELL1-Associated Membranous Nephropathy, SARS-CoV-2, biopsy, TGFBR3, crystalline nephropathies, Renal Intratubular Casts, viral-like inclusions, Covid-19, Anti-Brush Border Antibody Disease, MGMID, renal pathology, kidney research
Podcast

Anti-Brush Border Antibody Disease (Anti-LRP2 Nephropathy) Associated with Lupus Nephritis

Anti-brush border antibody disease is a rare autoimmune disease. Auto-antibodies are targeted against LRP2/Megalin, which is present on the apical…

By Dr. Rebecca May

lupus nephritis, kdigo connections, arkana laboratories, renal pathology
KDIGO Connections

KDIGO Connections: SLE Treatment and Definitions

How do you initially treat patients with active lupus nephritis?    

Membranous Lupus Nephritis, arkana laboratories, renal pathology, kidney biopsy
Teaching Points

Membranous Lupus Nephritis

The patient is a 19-year-old female who presents with hematuria, nephrotic range proteinuria, and a creatinine of 1.2 mg/dL. She…

Systemic Lupus Erythematosus, SLE, lupus nephritis, arkana laboratories, disease week, renal pathology
Disease Week

Disease Week: Lupus Nephritis

Monday: Introduction to Systemic Lupus Erythematosus and Clinical Diagnostic Criteria Answer: C. 50% 50% of adults with SLE will develop…


Lupus Nephritis Genetics
Art of Medicine

Art of Medicine: Lupus Nephritis Genetics

The above painting shows an image of a sequencing gel, which are produced by DNA synthesis in the presence of…

Systemic Lupus Erythematosus, SLE, lupus nephritis, arkana laboratories, disease week, renal pathology
Disease Week

NIH Lupus Nephritis Activity and Chronicity Indices

NIH Lupus Nephritis Activity and Chronicity Indices: A way to monitor response to treatment and disease progression. A semi-quantitative grading…

Systemic Lupus Erythematosus, SLE, lupus nephritis, arkana laboratories, disease week, renal pathology
Disease Week

International Society of Nephrology / Renal Pathology Society Classification of Lupus Nephritis

How do we classify lupus nephritis on a renal biopsy? SLE patients with an active urinary sediment or proteinuria may…


Systemic Lupus Erythematosus, SLE, lupus nephritis, arkana laboratories, disease week, renal pathology
Disease Week

Introduction to Systemic Lupus Erythematosus and Clinical Diagnostic Criteria

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which affects over 5 million people worldwide, and manifests as tissue…

Endocapillary hypercellularity, arkana laboratories, twitter poll
Twitter Poll

Twitter Poll (February 27, 2019)

Answer: B “Endocapillary hypercellularity” is the new term recommended to be used instead of “endocapillary proliferation”. This is a more…

Vanessa Moreno, MD
By Vanessa Moreno, MD
Lupus Nephritis, arkana laboratories, teaching point, nephropathology
Teaching Points

Lupus Nephritis (Class IV)

A 20-year-old female presents with hematuria, proteinuria, and a creatinine of 1.2 mg/dl. Serologies for ANA are positive. Complement levels…