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EXT1 And NCAM1-Associated Membranous Lupus Nephritis In A Cohort Of Patients Undergoing Repeat Kidney Biopsies
Systemic lupus erythematosus (SLE) is an autoimmune disease in which approximately 50% of patients have kidney involvement (lupus nephritis). Membranous…
Subepithelial Immune Deposits Carpeting the GBM Surface
Todays eyeSCANdy image of an acellular scanning EM from a biopsy with membranous lupus nephritis shows subepithelial immune deposits (arrows,…
Diagnose This (August 15, 2022)
What is this finding and what is the diagnosis? This is an H&E stain showing numerous hematoxylin bodies.…
Glomerular Basement Membrane With A Reticular Appearance And Occasional “Craters”
This acellular scanning EM from a biopsy with membranous lupus nephritis shows glomerular basement membrane (large arrow) with a reticular…
Subepithelial Immune Deposits Carpeting the GBM Surface
This acellular scanning EM from a biopsy with membranous lupus nephritis shows subepithelial immune deposits (not extracted) carpeting the GBM…
Transforming Growth Factor Beta Receptor 3 (TGFBR3)-Associated Membranous Nephropathy
Approximately half of lupus patients have kidney disease, including membranous glomerulopathy. On renal biopsy, immunofluorescence shows granular capillary loop deposits,…
(NCAM1) Neural Cell Adhesion Molecule 1 Is A Novel Autoantigen In Membranous Lupus Nephritis
Membranous nephropathy is a leading cause of nephrotic syndrome. On renal biopsy, immunofluorescence shows granular capillary loop deposits, and holes…
Disease Week: Lupus Nephritis
Monday: Day #1, Tweetorial #1: Welcome to a #DiseaseWeek highlighting lupus nephritis from @arkanalabs. Well present some daily Tweetorials to…
Anti-Brush Border Antibody Disease (Anti-LRP2 Nephropathy) Associated with Lupus Nephritis
Anti-brush border antibody disease is a rare autoimmune disease. Auto-antibodies are targeted against LRP2/Megalin, which is present on the apical…
KDIGO Connections: Lupus Nephritis Treatment and Definitions
How do you initially treat patients with active lupus nephritis?
Membranous Lupus Nephritis
The patient is a 19-year-old female who presents with hematuria, nephrotic range proteinuria, and a creatinine of 1.2 mg/dL. She…
Disease Week: Lupus Nephritis
Monday: Introduction to Systemic Lupus Erythematosus and Clinical Diagnostic Criteria Answer: C. 50% 50% of adults with SLE will develop…
Art of Medicine: Lupus Nephritis Genetics
The above painting shows an image of a sequencing gel, which are produced by DNA synthesis in the presence of…
NIH Lupus Nephritis Activity and Chronicity Indices
NIH Lupus Nephritis Activity and Chronicity Indices: A way to monitor response to treatment and disease progression. A semi-quantitative grading…
International Society of Nephrology / Renal Pathology Society Classification of Lupus Nephritis
How do we classify lupus nephritis on a renal biopsy? SLE patients with an active urinary sediment or proteinuria may…