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International Society of Nephrology / Renal Pathology Society Classification of Lupus Nephritis

Tiffany Caza, MD, PhD renal pathologist at arkana laboratories
By Tiffany Caza, MD

Jun 04, 2019

Systemic Lupus Erythematosus, SLE, lupus nephritis, arkana laboratories, disease week, renal pathology

How do we classify lupus nephritis on a renal biopsy? 

SLE patients with an active urinary sediment or proteinuria may undergo a kidney biopsy to evaluate for nephritis.  The International Society of Nephrology (ISN) and Renal Pathology Society (RPS) created a lupus nephritis classification system based on morphologic findings on kidney biopsies.  A simplified view of the lupus nephritis classification algorithm is based on the sites of immune deposits within glomeruli.  A flow-chart demonstrating that algorithm is shown below.   Mesangial immune deposits can be present in all classes.

SLE, glomerular immune deposits, arkana laboratories, How do we classify lupus nephritis on a renal biopsy? 

A summary in tabular format is shown below.  

ISN/RPS class, classification of lupus nephritis

While a majority of SLE patients who undergo kidney biopsy for nephritic or nephrotic syndrome have lupus nephritis, other findings that could be identified on kidney biopsy in lupus patients include, but are not limited to focal and segmental glomerulosclerosis, pauci-immune crescentic glomerulonephritis, acute interstitial nephritis, arterionephrosclerosis, and other vascular lesions.




Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.