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Twitter Poll (January 23, 2019)

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Jan 24, 2019

CLL/SLL Patients, arkana laboratories,


Although glomerular disease in patients with CLL/SLL is less common, the most frequent patterns of glomerular injury seen include MPGN (immune complex mediated), MCD, membranous GN, and monoclonal immunoglobulin deposition disease.

The most common form of kidney involvement in patients with CLL/SLL is the presence of direct infiltration of the kidney parenchyma by leukemic cells. Although glomerular disease in patients with CLL/SLL is less common, they can be present.  The glomerular pattern of injury frequently seen in these group of patients include membranoproliferative glomerulonephritis (immune complex mediated), minimal change disease, membranous nephropathy, and monoclonal immunoglobulin deposition disease (nonamyloid and amyloid).


Kowalewska J, Nicosia RF, Smith KD, Kats A, Alpers CE. Patterns of glomerular injury in kidneys infiltrated by lymphoplasmacytic neoplasms. Hum Pathol 2011; 42: 896–903

Poitou-Verkinder AL, Francois A, Drieux F, Lepretre S, Legallicier B, Moulin B, Godin M, Guerrot D. The spectrum of kidney pathology in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma: A 25-year multicenter experience. PLoS One 2015; 10(3): e0119156



Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.