ANSWER: D

Drug-induced AIN may account for 60-70% of AIN cases. Some offending drugs include: antibiotics, proton pump inhibitors, NSAIDs, PD1-inhibitors, anti-convulsants, and diuretics, among others.

References:

Cortazar FB et al. Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors. Kidney Int 2016; 90: 638-47

Muriithi AK et al. Clinical characteristics, causes and outcomes of acute interstitial nephritis in the elderly. Kidney Int 2015; 87: 458-464.

Muriithi AK et al. Biopsy-proven acute interstitial nephritis. Nat Rev Nephrol 2010; 6(8): 461-70

Praga M et al. Acute interstitial nephritis. Kidney Int 2010; 77(11): 956-61