In a recent article by Caza et al, NCAM-1 associated membranous nephropathy has been shown to be associated with systemic lupus erythematosus. Clinically, the article showed that the cases had a female predominance and were seen in younger patients than that typically seen in PLA2R or THSD7A-associated membranous nephropathy. In their cohort, NCAM-1-associated membranous made up approximately 7% of all membranous lupus nephritis cases (see reference).
Caza T, Hassen S, Kuperman M, et al (in press). Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis. Kid Int (2020) DOI: https://doi.org/10.1016/j.kint.2020.09.016.
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