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NCAM-1, NCAM-1 associated membranous nephropathy, PLA2R, Twitter Poll, Arkana Laboratories
Twitter Poll

Twitter Poll (November 11, 2020)

Answer: B In a recent article by Caza et al, NCAM-1 associated membranous nephropathy has been shown to be associated…

Membranous Glomerulopathy, PLA2R, Diagnose This, renal pathology, Arkana Laboratories
Diagnose This!

Diagnose This (August 17, 2020)

What is your diagnosis for this patient with nephrotic syndrome? …

Membranous Glomerulopathy Subtyping, Arkana Laboratories, Renal Pathology Teaching Points
Teaching Points

Membranous Glomerulopathy Subtyping

The diagnosis of membranous glomerulopathy has evolved rapidly in the past 10 years since the identification of PLA2R as the…

Arkana Laboratories, renal pathology, Membranous Nephropathy
Teaching Points

Resolving Membranous Nephropathy

A 40-year-old white male presents with 3 grams/24 hr of proteinuria and swelling around his ankles. He reports that he…

Membranous Glomerulopathy, Arkana Laboratories, KDIGO Connections, Renal Pathology
KDIGO Connections

KDIGO Connections: Membranous Diagnosis Algorithm

Have you seen the latest proposed KDIGO algorithm for the diagnosis and treatment of membranous glomerulopathy? Dr. Bourne brings us…

Membranous Nephropathy, renal diseases, kidney biopsy, arkana laboratories
Teaching Points

Membranous Nephropathy After Transplantation

The biopsy shows a recurrent membranous nephropathy within a transplant. Figure 1 shows “spikes” and “holes.” Figure 2 shows mild…

Disease Week, Membranous glomerulopathy, disease week, arkana laboratories
Disease Week

Disease Week: Membranous Glomerulopathy

Monday History of MG Timeline of major discoveries in membranous glomerulopathy.   Heymann nephritis was unique as a model of…

PLA2R-Positive Membranous Glomerulonephritis, PLA2R, KDIGO Connections, Arkana Laboratories
KDIGO Connections

KDIGO Connections: PLA2R-Positive Membranous Glomerulonephritis

KDIGO has some recommendations for anti-PLA2R testing in the research setting, but do you follow anti-PLA2R levels in your patients…

Membranous Glomerulopathy, Art of Medicine
Art of Medicine

Art of Medicine: Membranous Glomerulopathy

The painting above depicts membranous glomerulopathy. A single glomerular capillary loop with confluent subepithelial and intramembranous electron dense deposits along…

KDIGO, Membranous Glomerulopathy, KDIGO Connections, renal pathology
KDIGO Connections

KDIGO Connections: Membranous Glomerulopathy

Welcome to the first post in our new series KDIGO Connections, a series in which we are asking our nephrologist…

interstitium shows frequent clusters of interstitial foam cells
Teaching Points

Interstitial Foam Cells

This 52-year-old female underwent a renal biopsy as part of the workup for nephrotic syndrome. The biopsy is diagnostic for…

Immunohistochemical staining for PLA2R
Teaching Points

PLA2R Tutorial

The diagnosis of membranous glomerulopathy has been transformed in the past 10 years with the discovery of PLA2R. PLA2R is…

Negative PLA2RAb Serology
Twitter Poll

Twitter Poll (February 14, 2018)

ANSWER: B 10-15% of cases with renal biopsy findings consistent with PMN (positive PLA2R staining) can have negative PLA2RAb serology…

Vanessa Moreno, MD
By Vanessa Moreno, MD
Phospholipase A2 Receptor 1
Twitter Poll

Twitter Poll (December 14, 2017)

ANSWER: C Phospholipase A2 receptor 1 (PLA2R1) is present in podocytes and proximal tubules and has been detected in ~70%…

Vanessa Moreno, MD
By Vanessa Moreno, MD
renal biopsy showing positive PLA2R stain of glomerulus
Teaching Points


Autoantibody formation directed against PLA2R1 is the underlying etiology in most cases of primary membranous glomerulopathy. This new understanding of…