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Neuro Notes

Mild Nonspecific Changes with Significant Genetic Finding

Clinical History This 30-year-old patient presented with complaints of severe exertional muscle stiffness and pain, and similar symptoms upon exposure…

Neuro Notes

Segmental COX-Negative Fibers

Clinical History This 40-year-old female who presented with generalized muscle weakness, progressive ptosis and cognitive impairment. Question What of the…

Amyloid C5b-9
Neuro Notes

Amyloid C5b-9

Clinical History: This 64-year-old patient presents with progressive distal bilateral upper and lower extremity numbness and pain. They also reported…


focal relatively circumscribed collection of mononuclear histiocytes with admixed chronic lymphoid inflammation
Neuro Notes

Granulomatous Myopathy and Neuropathy

This 40-year-old patient presented with a three year history of slowly progressive generalized muscle weakness. More recently their hands and…

Polyglucosan bodies, Some of the muscle fibers in this image contain multiple refractile angular/rhomboid shaped well-circumscribed structures within the sarcoplasm
Neuro Notes

Muscle Inclusions

This 50-year-old patient presented with complaints of progressive leg weakness and dysesthesia (burning sensation) in a sock and glove distribution.…

Tissue Gram stain, inflamed skeletal muscle
Neuro Notes

Tissue Gram Stain

  This 50-year-old female presents with progressively worsening swelling and pain involving her left hip and buttock of four days…


Myopathy with Lobulated Muscle Fibers
Neuro Notes

Acquired Etiologies of Myopathy with Lobulated Muscle Fibers

An elderly male patient presents with a chief complaint of dull achy pain. The patient relates that the pain is…

By Kelly Mrachek, MD
Fibrous Body, neuro path, arkana laboratories, Muscle biopsy
Neuro Notes

Fibrous Body

A 75-year-old female patient presents with proximal muscle weakness, characteristic skin rash, and dysphagia. Laboratory workup reveals elevated CPK 3500.…

By Kelly Mrachek, MD