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Anti-Brush Border Antibody Disease
Art of Medicine

Art of Medicine: Anti-Brush Border Antibody Disease

The above painting shows massive tubular basement membrane (electron dense on EM) deposits along proximal tubules with sparing of the…

Chronic Uric Acid Nephropathy
Teaching Points

Chronic Uric Acid Nephropathy

Chronic uric acid nephropathy results from deposition within the renal parenchyma of monosodium urate monohydrate. While the disease may occur…

Granulomatous Interstitial Nephritis, renal biopsy, renal cortex
Teaching Points

Granulomatous Interstitial Nephritis Differential

This biopsy is from a 25-year-old African American female with renal failure. The photomicrographs here show renal involvement by non-caseating…


IgG4-Related Tubulointerstitial Nephritis
Teaching Points

IgG4-Related Tubulointerstitial Nephritis

IgG4-related disease is a systemic inflammatory and sclerosing disorder which may affect a wide range of different organs including the…

Armanni Ebstein Lesion
Teaching Points

Armanni Ebstein Lesion

Armanni-Ebstein lesion, originally described by Luciano Armanni in 1872, is characterized by vacuolization and PAS-positive glycogen accumulation within the cytoplasm…

Brush Border
Teaching Points

Brush Border

Do you know how the proximal tubule brush border is related to the Nobel Prize in Chemistry? Normal proximal tubules…


Granulomatous Interstitial Nephritis
Pushing Glass

Pushing Glass (September 20, 2017)

The patient is a 65-year-old African American female who presents with a protein/creatinine ratio of 2 and a serum creatinine…

IgG4-Related Disease
By L. Nich Cossey, MD
Chronic Active Tubulointerstitial Nephritis
Teaching Points

Chronic Active Tubulointerstitial Nephritis

Chronic tubulointerstitial nephritis in children may be secondary to a number of possible etiologies such as drug and other exogenous…


Chronic Active Tubulointerstitial Nephritis
Teaching Points

Chronic Active Tubulointerstitial Nephritis

39 y/o male presents with acute kidney injury, creatinine 3.5 mg/dl. Bland urinalysis, serologic studies negative. Immunofluorescence study of the…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD