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Twitter Poll (July 18, 2018)
ANSWER: 20-30% In a case series by Boils et al. which included 49 patients with GN due to IE, 28%…
Chronic Lesions of ANCA – Fibrous Crescents
Fibrous crescents can be differentiated from ischemic obsolescent glomeruli based on the pattern of global sclerosis. The fibrous crescent has…
Digging Deeper, Literally
This biopsy came from a 79-year-old patient. He had presented with acute renal failure. His serum creatinine was up to…
Chronic Lesions of ANCA – Arteritis
The renal biopsy shown here is from a patient with a remote history of ANCA-associated vasculitis. The artery present in…
Hidden Treasures
This biopsy came to us due to acute renal failure and proteinuria. The patient was a gentleman in his late…
Twitter Poll (February 21, 2018)
ANSWER: D ANCA-associated GN and anti-GBM GN are the most common causes of pulmonary-renal syndrome accounting for about 90% of…
Twitter Poll (February 1, 2018)
ANSWER: C Approximately 25-30% of the patients with anti-GBM crescentic glomerulonephritis are ANCA positive, usually for MPO-ANCA.
Twitter Poll (December 6, 2017)
ANSWER: A Dual positivity for MPO and PR3 antibodies is a strong clue for levamisole/cocaine DAV.
Endocarditis
Crescentic glomerulonephritis is most commonly an autoimmune-related glomerulonephritis (e.g. ANCA, anti-GBM disease, lupus nephritis). However, a recent case series (reference…
Renal Medullary Angiitis
This 56-year-old female presented with acute kidney injury, hematuria, and mild proteinuria. All serologic studies were negative except for antineutrophil…
Medullary Angiitis
The attached photomicrographs show the classic histopathology of renal medullary angiitis, a lesion involving the vasa recta of the medulla.…
Necrotizing Vasculitis
Necrotizing Vasculitis as seen with Silver Methenamine Massons Trichrome (SMMT) stain on a renal biopsy. The immunofluorescence panel was negative…
Necrotizing Vasculitis
Necrotizing vasculitis as shown using fluorescence with DAPI-FITC-Texas Red excitation on an H&E stained section. Subtle and not so subtle…