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Necrotizing Vasculitis

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD

Apr 28, 2017

Necrotizing Vasculitis

Necrotizing Vasculitis as seen with Silver Methenamine Masson’s Trichrome (SMMT) stain on a renal biopsy. The immunofluorescence panel was negative (pauci-immune). Renal biopsies contain small arteries and thus this is consistent with granulomatosis with polyangiitis (GPA). The biopsy was obtained from an 87-year-old male who presented with hematuria, proteinuria and a creatinine of 2.5 mg/dl. Following the biopsy, ANCA serologies were ordered and cANCA positivity was found.


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