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Disintegrating Capillary Loop
eyeSCANdy

Disintegrating Capillary Loop Riddled with Microperformations

This acellular scanning EM shows disintegrating capillary loop riddled with microperformations in a patient with crescentic glomerulonephritis. Photo credits to…

fibrinoid necrosis and crescent formation
Diagnose This!

Diagnose This (February 21, 2022)

In a patient with AKI and hematuria, what is your diagnosis? …

Diagnose This!

Diagnose This (February 14, 2022)

In a 25yo with sepsis post-cholecystectomy and C. diff colitis, what is your diagnosis? …


ANCA-associated vasculitis
Diagnose This!

Diagnose This (January 24, 2022)

In a patient with RPGN and this morphological finding on biopsy, what is the most likely diagnosis? …

glomerulus showing a fibrocellular crescent
eyeSCANdy

Glomerulus Showing Fibrocellular Crescent

Todays eyeSCANdy image shows acellular scanning EM with a glomerulus showing a fibrocellular crescent (bottom). Photo credits to Dr. Stephen…

Glomerulus Obliterated By A Fibrous Crescent
eyeSCANdy

Glomerulus Obliterated By A Fibrous Crescent

This EM image shows a glomerulus obliterated by a fibrous crescent Photo credits to Dr. Stephen Bonsib!


Endocarditis-Associated Glomerulonephritis, arkana laboratories, renal pathology teaching points
Teaching Points

Endocarditis-Associated Glomerulonephritis

The patient is a 45-year-old IV drug user who presents with fevers, chills, hematuria, and fatigue. On laboratory testing, he…

ANCA-mediated glomerulonephritis, arkana laboratories, renal pathology, kidney biopsy
Diagnose This!

Diagnose This (June 24, 2019)

Immunofluorescence shows C3 (2-3+), IgM (1+), kappa (trace) and lambda (trace). What is your diagnosis?   …

By L. Nich Cossey, MD
ANCA Refactory, ANCA, KDIGO Connections, Arkana Laboratories, renal pathology, nephropathology
KDIGO Connections

KDIGO Connections: ANCA Refactory

How do you manage your patients who have refractory ANCA-related glomerulonephritis?    


anca-associated-glomerulonephritis, art of medicine
Art of Medicine

Art of Medicine: ANCA-Associated Glomerulonephritis

The painting above shows a crescentic glomerulonephritis and necrotizing arteritis. A mixed interstitial inflammatory infiltrate is shown in the top…

Alport Syndrome, Digging Deeper, Arkana laboratories, renal pathology, kidney pathology, nephropathology
Digging Deeper

Digging Deeper, or How We Never Quit

We received the biopsy from a 25-year-old female who presented for evaluation of nephrotic range proteinuria. Lab evaluation reveals a…

By Nidia Messias, MD
Anti-GBM, renal pathology , diagnose this!, arkana laboratories
Diagnose This!

Diagnose This (January 21, 2019)

A limited sample showed this lesion and negative staining on paraffin-retrieved IF tissue. What is your diagnosis? …

By L. Nich Cossey, MD

ANCA Disease, LECT2 Amyloid, IgG4-Related Disease, AL amyloidosis, ANCA, digging deeper, Dr. Messias, Arkana Laboratories, pathology diseases
Digging Deeper

Digging Deeper – Here, There, and Everywhere

This biopsy came from an elderly gentleman in his 80s, who presented with acute renal failure. His serum creatinine had…

By Nidia Messias, MD
endocarditis-associated glomerulonephritis in renal biopsy at Arkana Laboratories
Diagnose This!

Diagnose This (December 3, 2018)

What is your diagnosis? What would you want to confirm your diagnosis?       …

By L. Nich Cossey, MD
ANCA-Mediated Vasculitis
Diagnose This!

Diagnose This (August 20, 2018)

What is your presumed diagnosis in the absence of immunofluorescence and electron microscopy? …

By L. Nich Cossey, MD