April 2, 2018
Diagnose This (April 2, 2018)
What is the most likely diagnosis?
The photomicrograph shows endocapillary proliferation with exuberant intracapillary neutrophils. And, by immunofluorescence IgG and C3 were noted (see below). This pattern of injury is most commonly found in infection-associated glomerulonephritis which was the case here. Of note, neutrophil-rich intracapillary infiltrates, while most commonly associated with infection-associated glomerulonephritis, are not specific and can sometimes be seen in other diseases such as cryoglobulinemic glomerulonephritis, paraprotein-associated glomerulonephritis, and C3 glomerulonephritis as well as others.