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April 2, 2018

Diagnose This (April 2, 2018)

What is the most likely diagnosis?

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The photomicrograph shows endocapillary proliferation with exuberant intracapillary neutrophils. And, by immunofluorescence IgG and C3 were noted (see below). This pattern of injury is most commonly found in infection-associated glomerulonephritis which was the case here. Of note, neutrophil-rich intracapillary infiltrates, while most commonly associated with infection-associated glomerulonephritis, are not specific and can sometimes be seen in other diseases such as cryoglobulinemic glomerulonephritis, paraprotein-associated glomerulonephritis, and C3 glomerulonephritis as well as others.