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January 8, 2018

Diagnose This! (January 8, 2018)

The immunofluorescence image shown is of IgA. What is the most likely diagnosis and clinical history?

 

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This IgA stain shows mesangial dominant deposition of the immunoreactant and mesangial expansion with overlying capillary loops that appear unremarkable. These findings are most suggestive of an IgA nephropathy. While IgA nephropathy can present clinically in many different ways, hematuria is usually present and is the most common presentation. It shows peak incidence in the second and third decades, has a 2:1 male to female ratio in North American populations, and is more common in East Asians and Caucasians.