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Nephronophthisis by Light Microscopy
Nephronophthisis is an autosomal recessive tubulointerstitial nephropathy that is a leading genetic etiology of end-stage renal disease in children and…
Anti-VEGF Effect
This biopsy was taken from an older adult man with acute kidney injury and non-nephrotic range proteinuria. His medical history…
Smoking-Related Glomerulopathy
A renal biopsy was performed on this 52-year-old male with a history of hypertension and heavy tobacco use, who is…
Nephronophthisis by ISH
Nephronophthisis is an autosomal recessive tubulointerstitial nephropathy that is a leading genetic etiology of end stage renal disease in children…
HIV-Related Kidney Disease: HIVAN
This biopsy is taken from a patient with HIV/AIDS who presented with an elevated serum creatinine and nephrotic range proteinuria.…
Diabetic Glomerulosclerosis with Superimposed Diseases
Diabetic glomerulosclerosis is one of the most common causes of nephrotic range proteinuria in adults. When the clinical course of…
Peritubular Giant Cells
When giant cells surround tubules This renal biopsy was taken from a young woman with elevated serum creatinine (4.3 mg/dL),…
Chronic Lesions of ANCA – Fibrous Crescents
Fibrous crescents can be differentiated from ischemic obsolescent glomeruli based on the pattern of global sclerosis. The fibrous crescent has…
Hemoglobin Casts
This 58-year-old African American male without significant past medical history presents with fatigue and weakness. During workup, he was found…
Light Chain Deposition Disease
The immunofluorescence in cases of monoclonal immunoglobulin deposition disease is characterized by linear tubular basement membrane staining. In these cases,…
The “C” in CKD
This renal biopsy illustrates severe chronic kidney injury and its effects on all major compartments of the cortex: most glomeruli…
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
This renal biopsy from a 57-year-old male with acute renal failure, hematuria, and nephrotic-range proteinuria shows a proliferative glomerulonephritis (A)…
Immunotactoid Glomerulopathy
Immunotactoid glomerulopathy is one of many glomerular diseases characterized by organized deposits. Figure 1 shows characteristic glomerular changes seen with…
Focal Segmental Glomerulosclerosis (FSGS), Tip Variant
This biopsy was performed on a 9-year-old female with no significant past medical history, who presents with nephrotic syndrome. The…
Light Chain Proximal Tubulopathy Without Crystals Tutorial
The two most common morphologic variants of light chain proximal tubulopathy (LCPT) are LCPT with and without crystal formation. The…