Tubulointerstitial nephritis with uveitis (TINU) was first described as a distinct entity by Dobrin, et al. in 1975. TINU primarily affects young females (median age 15 years) who commonly have associated systemic signs and symptoms of the disease including weight loss, fever, fatigue, malaise, abdominal or flank pain, arthralgias or myalgias, and headache. The syndrome is likely underdiagnosed as a result of the asynchronous presentation of the renal and ocular symptoms. In fact, the ocular symptoms lag behind the interstitial nephritis diagnosis in two-thirds of cases by up to 14 months. TINU should be considered a diagnosis of exclusion only...