- Published: February 13, 2017
- By: L. Nich Cossey, MD and Arkana Author
- Tags: ABBA, Acute kidney injury, Anti-brush border antibody disease, Anti-LRP2 nephropathy, Megalin, Membranous glomerulopathy, Tubulointerstitial nephritis
Please pick the best answer. These images show characteristic findings of which of the following diseases: A) IgG4-Related Disease B) Lupus Nephritis C) Sjögren’s Syndrome-Related Tubulointerstitial Injury D) Anti-Brush Border Antibody Tubulointerstitial Nephritis E) Aristolochic Acid Nephropathy F) Mesoamerican Nephropathy Answer: D. Immune complex tubulointerstitial nephritis due to autoantibodies to the proximal tubule brush border is a recently described entity arising from IgG autoantibodies targeting the proximal tubule brush border. Associated immune complex deposits were also reported within the proximal tubule basement membranes and focal, segmental subepithelial space, reminiscent of early membranous glomerulopathy. Further reading: https://www.ncbi.nlm.nih.gov/pubmed/26334028
